Analysis of the potential impact of clinical pharmacist participation in antimicrobial stewardship programs on the incidence of antimicrobial-related adverse events in hospitalized patients
Objective To observe the potential impact of clinical pharmacist participation in antimicrobial stewardship programs on the incidence of antimicrobial-related adverse events in hospitalized patients.Methods 80 hospitalized patients were selected as the study subjects,and were divided into antimicrobial management group and conventional intervention group according to random numerical table,each consisting of 40 cases.The conventional intervention group was given conventional antibacterial drugs,and the antibacterial management group was given antimicrobial stewardship programs with the participation of clinical pharmacists.The use of antibiotics,the irrational drug use and the occurrence of adverse drug events were compared between the two groups.Results The rate of antimicrobial drug use,duration of antimicrobial drug use and cost of antimicrobial drug of the conventional intervention group were 20.00%,(12.37±2.14)d and(1011.90±29.60)yuan,while those of the antimicrobial management group were 5.00%,(9.13±1.60)d and(920.58±29.64)yuan.Compared with the conventional intervention group,the antimicrobial management group had a significantly lower rate of antimicrobial drug use,a significantly shorter duration of antimicrobial drug use,and a significantly lower cost of antimicrobial drug(P<0.05).The irrational drug use rate of the antimicrobial management group was 12.50%,which was obviously lower than 50.00%of the conventional intervention group(P<0.05).The incidence of adverse drug events of the antimicrobial management group was 15.00%,which was lower than 35.00%in the conventional intervention group(P<0.05).Conclusion Clinical pharmacists'participation in the antimicrobial stewardship programs can reduce the use of antimicrobial drugs,increase their rational use,reduce the irrational use of antimicrobial drugs,and effectively reduce the occurrence of adverse drug events.
万方数据
维普
