Objective To explore the risk factors for recurrence in pediatric primary malignant extracranial germ cell tumor(MGCT).Methods A retrospective analysis was conducted on clinical data of pediatric patients diagnosed and treated for MGCT from January 2010 to December 2019.Logistic regression analysis was used to identify high-risk factors for recurrence in MGCT patients.Kaplan-Meier analysis was performed to compare the overall survival(OS)and event-free survival(EFS)rates among different factors.Results A total of 109 pediatric patients with MGCT were included.The 5-year OS and EFS rates were(91.3±2.8)％and(86.5±3.4)％,respectively.The recurrence rate was 12.8％,the sacrococcygeal region being the main site of recurrence(9/14).There were significant differences between the recurrence group and the non-recurrence group in terms of the primary site(x2=18.45,P＜0.01),COG stage(x2=11.32,P＜0.01),metastasis status(x2=12.80,P＜0.01),liver metastasis(x2=15.29,P＜0.01),and lung metastasis(x2=9.57,P＜0.001).Logistic regression analysis revealed that the sacrococcygeal region was an independent risk factor for recurrence.The OS rate in the recurrence group(59.1±1.4)％was lower than that in the non-recurrence group(95.7±2.1)％,and the OS rate in the incomplete resection group(65.8±1.4)％was lower than that in the complete resection group(94.5±2.4)％,with both differences being statistically significant.Conclusions Patients with recurrent MGCT or incomplete tumor resection have a poor prognosis,and the sacrococcygeal region is an independent risk factor for recurrence in MGCT patients.
关键词
恶性颅外生殖细胞肿瘤/复发/骶尾部手术
Key words
Malignant extracranial germ cell tumor/Recurrence/Sacrococcygeal region
维普
万方数据