Objective To investigate arsenic concentration in tissues and health-related quality of life in pediatric acute promyelocytic leukemia(APL)treated with arsenicals.Methods A cross-sectional study was conducted from July 11,2022,to September 7,2022,during which 36 children with acute promyelocytic leukemia(APL)and 17 healthy children(control group)were enrolled.Plasma,urine,hair,and nail samples were collected from study subjects,and arsenic concentrations in various tissues were determined.The Chinese version of the PedsQL 4.0 Generic Core Scales was employed to assess the health-related quality of life in children with acute lymphoblastic leukemia(APL).Results Arsenic retention in plasma,urine,hair and nail from patients who had been off the arsenic-containing treatment for less than 3 months were higher than the controls,respectively.Twenty-six APL children completed the Chinese version of PedsQL4.0and in the dimensions of physiological functioning,emotional functioning,social functioning,school performance,and overall scores,there were no statistically significant differences between different arsenic concentration groups.The scores in each dimension were generally close to those of the normal population.Conclusions After the application of arsenicals(ATO and RIF),arsenic concentrations in the tissues of APL patients are elevated within 3 months and return to normal after 3 months.Moreover,no differences in health-related quality of life were observed among children with acute promyelocytic leukemia at different arsenic concentrations,suggesting that arsenic concentration in the tissues of children with acute promyelocytic leukemia is not a direct influencing factor on health-related quality of life.
关键词
急性早幼粒细胞白血病/儿童/砷浓度/生活质量
Key words
Acute Lymphoblastic Leukemia/Childhood/Arsenic Concentration/Quality of Life
维普
万方数据