Objective To compare the differences of hematopoietic reconstitution and prognosis between Haplo-HSCT,UCB-HSCT,MDS-HSCT and MUD-HSCT in acute lymphoblastic leukemia(ALL)pediatric patients.Methods The clinical data of 230 ALL pediatric patients who underwent allo-HSCT from August 2012 to January 2022 in the children's Hospital of Soochow University were included.The differences of hematopoietic reconstitution,prognostic characteristics and prognostic factors were analyzed retrospectively.Results Of the 230 patients,228 patients had achieved neutrophil engraftment for 13(9-33)days,and 208 patients had successful platelet engraftment for 16(3-93)days.The neutrophil engraftment time of UCB-HSCT was 16(10-33)days and the platelet engraftment time of UCB-HSCT was 34(15-93)days,both significantly longer than that of other hemopoietic methods(P＜0.05).The rate of platelet implantation was 76％,which was significantly lower than that of other hemopoietic methods(P＜0.05).The 5-years overall survival rates of Haplo-HSCT,UCB-HSCT,MSD-HSCT and MUD-HSCT were 75.6％,68％,70.6％and 75％respectively,with no significant differences(P＞0.05).There was no significant differences in recurrent rate(RR)among Haplo-HSCT,UCB-HSCT and MUD-HSCT(P＞0.05),the RR of MSD-HSCT was significantly higher than the other three transplantation methods(P＜0.05).Conclusions Although the hematopoietic reconstitution rate and hematopoietic reconstitution time of UCB-HSCT are significantly lower than that of other transplantation methods,there is no significant difference in the overall prognosis.Haplo-HSCT is not inferior to MSD-HSCT and MUD-HSCT in the treatment of ALL,Haplo-HSCT and UCB-HSCT can be used as an important alternative donor.
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