3D生物打印技术在耳廓修复重建中的应用研究进展
Research progress of three-dimensional bioprinting technology in auricle repair and reconstruction
陈小雷 1胡浩磊 2李谊 2岳玮 2张秀静 3沈德新 2麻文来 2邢培梅 2张亚戈 2关泰红2
作者信息
- 1. 新乡医学院(河南新乡 453003)
- 2. 中国人民解放军联勤保障部队第九八八医院耳鼻咽喉科(郑州 450042)
- 3. 中国人民解放军总医院京南医疗区复兴路门诊部(北京 100089)
- 折叠
摘要
目的 对3D生物打印技术在耳廓修复重建方面的应用研究进展作一综述.方法 广泛查阅近年来国内外3D打印与耳廓修复重建相关研究文献,对3D生物打印技术概念及其在耳廓修复重建中的应用研究进展进行总结.结果 耳廓具有复杂解剖结构和功能,需要精确的组织重建和形态复制,因此3D打印技术在耳廓修复重建方面具有巨大应用潜力.与传统3D打印技术相比,3D生物打印技术不仅能模拟耳廓外形结构,还能将细胞与材料混合打印,在支架成型过程中实现细胞在支架内部精准分布,模拟天然组织组成及结构,更有利于构建具有生物活性功能的耳廓组织,从而提高修复效果.结论 3D生物打印技术可以重建耳廓组织,能避免传统自体软骨移植相关并发症,寻找既符合耳廓组织机械性要求,又符合生物要求的生物墨水是目前研究的主要挑战.
Abstract
Objective To review the research progress on the application of three-dimensional(3D)bioprinting technology in auricle repair and reconstruction.Methods The recent domestic and international research literature on 3D printing and auricle repair and reconstruction was extensively reviewed,and the concept of 3D bioprinting technology and research progress in auricle repair and reconstruction were summarized.Results The auricle possesses intricate anatomical structure and functionality,necessitating precise tissue reconstruction and morphological replication.Hence,3D printing technology holds immense potential in auricle reconstruction.In contrast to conventional 3D printing technology,3D bioprinting technology not only enables the simulation of auricular outer shape but also facilitates the precise distribution of cells within the scaffold during fabrication by incorporating cells into bioink.This approach mimics the composition and structure of natural tissues,thereby favoring the construction of biologically active auricular tissues and enhancing tissue repair outcomes.Conclusion 3D bioprinting technology enables the reconstruction of auricular tissues,avoiding potential complications associated with traditional autologous cartilage grafting.The primary challenge in current research lies in identifying bioinks that meet both the mechanical requirements of complex tissues and biological criteria.
关键词
3D生物打印技术/耳廓修复重建/组织工程支架/生物墨水Key words
Three-dimensional bioprinting technology/auricle repair and reconstruction/tissue engineered scaffold/bioink引用本文复制引用
基金项目
河南省医学科技计划项目(LHGJ20230698)
出版年
2024
NETL
NSTL
万方数据