肥胖相关性心力衰竭的研究进展
Research Progress in Obesity Related Heart Failure
安琪尔 1陈燕燕1
作者信息
- 1. 中国医学科学院 北京协和医学院 国家心血管病中心 阜外医院 内分泌中心,北京 100037
- 折叠
摘要
心力衰竭是严重危害人类健康的主要心血管疾病之一.近年来,心力衰竭患病率逐年上升,部分原因来自超重和肥胖人群的快速增长.肥胖作为心力衰竭的独立危险因素,通过脂肪细胞释放脂肪因子、胰岛素抵抗和心外膜脂肪组织积累等机制,影响血液动力学、心脏结构与功能.目前对于减重是否能给心力衰竭患者带来直接获益,研究结果尚不一致,但体重减轻可使心力衰竭症状及合并症减轻,并改善患者生活质量.减重在肥胖人群心血管疾病的预防和管理中发挥不可或缺的作用.具有循证证据的减重措施主要包括生活方式干预、药物治疗和减重手术.
Abstract
The prevalence rate of heart failure is increasing year by year,posing a significant threat to human health,partly due to the rapid growth of overweight and obese populations.Obesity,as an independent risk factor of heart failure,affects hemodynamics,cardiac structure and cardiac function through mechanisms such as adipocyte release of adipokines,insulin resistance and accumulation of epicardial adipose tissue.Although the results of whether weight loss can reduce heart failure incidence are inconsistent,weight loss is associated with benefits such as reduced symptoms and comorbidities,and improved quality of life.Weight loss thus plays an indispensable role in the prevention and management of cardiovascular diseases in obese individuals.Currently,effective weight loss strategies confirmed by evidence-based studies mainly include lifestyle interventions,medication therapy and weight loss surgery.
关键词
心力衰竭/肥胖/心脏重构/减重Key words
heart failure/obesity/heart remodeling/weight loss引用本文复制引用
基金项目
国家临床重点专科建设项目(自主申报项目)(2022)()
高水平医院临床科研业务费项目(2022-GSP-TS-7-YIRI)
北京市临床重点专科建设项目(2023)()
出版年
2024
NETL
NSTL
维普
万方数据