摘要
目的:探究 40 岁及以下青年高血压人群臂间收缩压差异(sIAD)的影响因素.方法:选取参加 2010～2020 年体检的 40 岁及以下青年开滦职工 12 895 例,均获取卧位同步测量四肢血压值,按照性别、年龄(±1 岁)1∶1 匹配高血压组(n=3 584)和非高血压组(n=3 584),每组再进一步根据sIAD分为sIAD＜10 mmHg(1 mmHg=0.133 kPa)者和sIAD≥10 mmHg者.采用逐步多因素Logistic回归模型分析两组sIAD≥10 mmHg的影响因素.结果:高血压组的sIAD≥10 mmHg检出率高于非高血压组(31.72%vs.27.76%,P＜0.001).逐步多因素Logistic回归结果显示,高血压人群中,踝臂指数(ABI)＜0.9、男性、肥胖、超重、低密度脂蛋白胆固醇(LDL-C)水平升高、收缩压升高均与sIAD≥10 mmHg呈正相关(P均＜0.05);大学及以上学历、体育锻炼均与sIAD≥10 mmHg呈负相关(P均＜0.05).非高血压人群中,ABI＜0.9、收缩压升高均与sIAD≥10 mmHg呈正相关(P均＜0.05);年龄增长与sIAD≥10 mmHg呈负相关(P均＜0.05).结论:青年高血压人群sIAD≥10 mmHg检出率高于青年非高血压人群.ABI降低、男性、肥胖、超重、LDL-C水平升高、收缩压升高、大学及以上学历和体育锻炼是青年高血压人群sIAD≥10 mmHg的影响因素.
Abstract
Objectives:To explore the influencing factors of inter-arm systolic blood pressure difference(sIAD)in young hypertensive population.Methods:A total of 12 895 young Kailuan employees aged≤40 years,who participated in the physical examination from 2010 to 2020,were enrolled in this study.All of them underwent blood pressure measurements of four limbs in supine position.Young hypertensive group(n=3 584)and young non-hypertensive group(n=3 584)were 1∶1 matched by sex and age(±1 year),and participants were further divided into sIAD＜10 mmHg(1 mmHg=0.133 kPa)and sIAD≥10 mmHg subgroups.A stepwise multivariate logistic regression model was established to analyze the determinants of sIAD≥10 mmHg.Results:The detection rate of sIAD≥10 mmHg was significantly higher in the young hypertensive group than in the young non-hypertensive group(31.72%vs.27.76%,P＜0.001).Stepwise multivariate logistic regression analysis showed that in young hypertensive population,ankle-brachial index(ABI)＜0.9,male,obesity,overweight,elevated low density lipoprotein cholesterol(LDL-C)level,and systolic blood pressure were positively associated with sIAD≥10 mmHg,while college education or above,physical exercise were negatively correlated with sIAD≥10 mmHg(all P＜0.05).In the young non-hypertensive population,ABI＜0.9,systolic blood pressure were positively correlated with sIAD≥10 mmHg,while age was negatively associated with sIAD≥10 mmHg(all P＜0.05).Conclusions:The detection rate of sIAD≥10 mmHg is higher in young hypertensive population than in young non-hypertensive population.Decreased ABI,male sex,obesity,overweight,increased LDL-C level,systolic blood pressure,college education and above,and physical exercise are the influencing factors of sIAD≥10 mmHg in young hypertensive population.
基金项目
河北省2021年度医学科学研究课题计划项目(20211802)
维普
万方数据