Correlation Between Peak Oxygen Consumption and Atrial Fibrillation in Patients With Hypertrophic Obstructive Cardiomyopathy
Objectives:To explore the characteristics of patients with hypertrophic obstructive cardiomyopathy(HOCM)with different peak oxygen consumption(PeakVO2)levels and the correlation between PeakVO2 and atrial fibrillation.Methods:A total of 188 patients,who were diagnosed with HOCM and underwent cardiopulmonary function test from December 2018 to September 2021 in the Adult Surgery Centert of Fuwai Hospital,were enrolled in this retrospective study.The general information,clinical history,results of preoperative serological test,echocardiography,cardiopulmonary function test and 24 h electrocardiogram of the patients were collected.Patients were divided into high oxygen consumption group(n=94)and low oxygen consumption group(n=94)according to the median peak oxygen consumption PeakVO2.Univariate and multivariate Logistic regression analysis were performed to explore the correlation between PeakVO2 and atrial fibrillation in HOCM patients.Results:The median age of the total cohort was 51.0(36.0,58.0)years old,the average PeakVO2 was(16.42±4.07)ml/(kg·min),and the incidence of atrial fibrillation was 16.5%.Compared with the high oxygen consumption group,patients in the low oxygen consumption group were older(P＜0.001),proportion of female(P=0.001),body mass index(P=0.004),and left atrial diameter(P＜0.001)were significantly higher.NT-proBNP(P=0.037)and NYHA classification(P=0.046)were also higher in the low oxygen consumption group than in high oxygen consumption group.Univariate regression analysis showed that age(P=0.021),symptoms of palpitation(P=0.005)and dizziness(P=0.001),left atrial diameter(P＜0.001),left ventricular outflow tract pressure(P=0.019)and PeakVO2(P＜0.001)were risk factors of atrial fibrillation.After adjusting age,sex,body mass index and other confounders,multivariate regression analysis showed that PeakVO2 remained as independent influencing factor of atrial fibrillation in HOCM patients(OR=0.847,95%CI:0.722-0.983,P=0.034).Conclusions:Lower PeakVO2 is independently related to the presence of atrial fibrillation in patients with hypertrophic obstructive cardiomyopathy.
NETL
NSTL
万方数据
