Clinical Characteristics of Cardiovascular Sequelae of Coronavirus Disease-2019
Objectives:To analyze the clinical characteristics of patients with cardiovascular sequelae post coronavirus disease-2019.Methods:The clinical profile was retrospectively analyzed in patients who complained of"repeated chest tightness,palpitations and fatigue"after coronavirus disease-2019(sequelae group,n=48)between December 2022 and August 2023,compared hospitalized patients with coronavirus disease-2019 history and no above symptoms during the same period(control group,n=32).Results:Proportion of sex and mean age were similar between the two groups.In sequela group,pulmonary CT showed no inflammatory infiltrates,and the results of white blood cell count,erythrocyte sedimentation rate,C-reactive protein,interleukin-6,D-dimer,and brain natriuretic peptide were all in the normal range.Cardiac troponin I was also negative in sequela group.Echocardiography examination showed that there were no left ventricular systolic and diastolic abnormalities and pericardial effusion in the sequela group.19 patients(39.6%)of them underwent pulmonary artery CT angiography(CTA)to exclude pulmonary embolism,and 9 patients(18.8%)underwent 3T cardiac magnetic resonance gadolinium enhancement examination,late gadolinium enhancement(LGE)was positive in 2 patients(22.2%).Coronary angiography was performed in 14 patients in the sequelae group and in all patients in the control group,coronary slow flow was found in 12 patients(85.7%)in the sequelae group and 6 patients(18.8%)in the control group(P＜0.001).Left biceps brachii artery angiography was performed in 8 patients post coronary angiography in the sequelae group,7 patients(87.5%)exhibited slow flow.Heart rate variability was lower in the sequelae group than in the control group(standard deviation of the RR intervals[SDNN]:[67.20±14.41]ms vs.[93.03±22.19]ms,P＜0.01;root mean square of the successive differences of inter-beat intervals[rMSSD]:[22.33±13.69]ms vs.[41.18±17.52]ms,P＜0.01;percentage of R-R intervals that are by at least 50 ms different from the previous interval[pNN50]:[5.8±4.9]%vs.[8.8±6.8]%,P＜0.05).Conclusions:Our study identifies multi-tissue microcirculation disorder and long-term autonomic imbalance in patients with cardiovascular sequelae post coronavirus disease-2019,which may represent as a potential reason and therapeutic target for long coronavirus disease-2019.
NETL
NSTL
万方数据
