The Potential Association of Childhood Body Mass Index and Birth Weight With Future Gestational Hypertension and Preeclampsia-eclampsia:a Mendelian Randomization Study
Objectives:To explore the potential association of childhood body mass index(BMI)and birth weight with future gestational hypertension and preeclampsia-eclampsia using two-sample Mendelian randomization(MR)analysis.Methods:Single nucleotide polymorphisms(SNP)were used as instrumental variables and SNP associated with childhood BMI and birth weight were selected from genome-wide association studies(GWAS)data.MR Egger regression,inverse variance weighting(IVW)and weighted median methods were used to investigate the potential association of childhood body mass index and birth weight with future gestational hypertension and preeclampsia-eclampsia.Results:The risk of future gestational hypertension(the multiplicative random effects IVW:OR=1.417,95%CI:1.144-1.755,P=0.001;weighted median:OR=1.277,95%CI:1.028-1.587,P=0.027)and preeclampsia-eclampsia(IVW:OR=1.399,95%CI:1.130-1.733,P=0.002)increased with increasing BMI in childhood.There was no association between genetically proxied birth weight and future gestational hypertension and preeclampsia-eclampsia.Sensitivity analysis supported the robustness of the defined association.Conclusions:There is a positive association of childhood body mass index with future gestational hypertension and preeclampsia-eclampsia.
childhood body mass indexbirth weighthypertensive disorders in pregnancyMendelian randomization
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NSTL
万方数据
