Research Progress on the Impaired Efferocytosis in the Pathogenesis of Atherosclerosis
Atherosclerosis is a chronic inflammatory disease characterized by abnormal lipid deposition and infiltration of inflammatory cells in the vessel wall.It is also the common pathological basis for various cardiovascular diseases such as acute myocardial infarction and ischemic stroke.The pathogenesis of atherosclerosis has not been fully elucidated.Efferocytosis refers the effective clearance of apoptotic cells by professional and non-professional phagocytes.In recent years,a large number of studies have found that impaired efferocytosis plays a key role in the progression of atherosclerotic plaques.Therefore,this article focuses on the impaired efferocytosis in atherosclerosis,exploring the mechanisms and intervention measures,in order to provide theoretical basis and thoughts on new therapeutic strategies for the prevention and treatment of atherosclerosis-related diseases.
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