累积空腹血糖水平与冠状动脉钙化的关联
Association Between Cumulative Fasting Blood Glucose and Coronary Artery Calcification
李晨阳 1刘芳超 1陈恕凤 1李建新 1曹杰 1黄克勇 1赵连成 1李莹 1黄建凤 1吕滨 2鲁向锋 1顾东风1
作者信息
- 1. 中国医学科学院 北京协和医学院 国家心血管病中心 阜外医院 心血管流行病学重点实验室 流行病研究部,北京 102300
- 2. 中国医学科学院 北京协和医学院 国家心血管病中心 阜外医院 放射影像科,北京 100037
- 折叠
摘要
目的:探讨累积空腹血糖水平与冠状动脉钙化(CAC)的关联.方法:选取来自北京社区动脉粥样硬化队列的 1 113 例研究对象,所有研究对象分别于 1998 年、2008～2009 年、2013～2014 年进行人体测量和血糖等生化指标检测,并于 2013～2014 年进行冠状动脉CT检查.根据累积空腹血糖水平(至少两次空腹血糖的 10 年加权累积水平)将研究对象分为四组:<50.0 mmol/L组(n=495)、50.0～55.9 mmol/L组(n=345)、56.0～69.9 mmol/L组(n=176)及≥70.0 mmol/L组(n=97).CAC评分>0 分定义为存在CAC.应用Logistic回归模型分析累积空腹血糖水平对CAC的影响,并根据性别、年龄等进行亚组分析.结果:1 113 例研究对象的平均年龄为(59.7±6.4)岁,其中男性 523 例(47.0%),478 例(42.9%)存在CAC.随着累积空腹血糖水平升高,CAC比例逐渐增加.多因素Logistic回归分析显示,与累积空腹血糖水平<50.0 mmol/L组相比,50.0～55.9 mmol/L组、56.0～69.9 mmol/L组及≥70.0 mmol/L组研究对象存在CAC的OR(95%CI)分别为1.43(1.04～1.98)、1.92(1.24～2.99)和 2.79(1.35～5.77)(Ptrend<0.05).累积空腹血糖水平每升高 10 mmol/L,CAC风险增加 34%(OR=1.34,95%CI:1.12～1.59,P<0.05).在各亚组中,累积空腹血糖水平每升高 10 mmol/L的CAC风险差异无统计学意义(P均≥0.05).结论:累积空腹血糖水平升高是CAC的危险因素,提示长期维持健康血糖水平的重要性.
Abstract
Objectives:This study aims to investigate the association between cumulative fasting blood glucose(FBG)and presence of coronary artery calcification(CAC).Methods:A total of 1 113 participants were recruited from the Beijing Community-based Cohort of Atherosclerosis.Anthropometric measurements and laboratory examinations including FBG were performed in 1998,2008-2009 and 2013-2014 respectively,and coronary CT scan was performed in 2013-2014.Participants were classified into 4 groups according to the level of cumulative FBG(10-year weighted cumulative value of at least 2 FBGs):<50.0 mmol/L group(n=495),50.0-55.9 mmol/L group(n=345),56.0-69.9 mmol/L group(n=176),and≥70.0 mmol/L group(n=97).CAC score>0 was defined as presence of CAC.Multivariable logistic regression model was applied to analyze the impact of cumulative FBG exposure on the risk of CAC,and subgroup analyses were conducted according to factors such as sex and age.Results:The mean age of enrolled participants was(59.7±6.4)years,523(47.0%)were male and 478(42.9%)had CAC.The proportion of subjects with CAC increased with the increment of cumulative FBG.Compared with the<50.0 mmol/L group,the multivariable-adjusted OR(95%CI)for CAC in the 50.0-55.9 mmol/L group,56.0-69.9 mmol/L group,and≥70.0 mmol/L group were 1.43(1.04-1.98),1.92(1.24-2.99)and 2.79(1.35-5.77),respectively(Ptrend<0.05).The risk for CAC increased by 34%per 10 mmol/L increase in cumulative FBG,with OR(95%CI)of 1.34(1.12-1.59).There was no statistically significant difference in the risk of CAC presence for each 10 mmol/L increase in cumulative FBG level between the subgroups(all P≥0.05).Conclusions:Elevated cumulative FBG is a risk factor for the prevalence of CAC,indicating the importance of maintaining healthy FBG in preventing the occurrence of CAC.
关键词
累积空腹血糖/冠状动脉钙化/冠状动脉钙化评分/危险因素Key words
cumulative fasting blood glucose/coronary artery calcification/coronary artery calcification score/risk factor引用本文复制引用
基金项目
国家重点研发计划(2021YFC2500500)
国家自然科学基金(82322059)
中国医科院医学与健康科技创新工程项目(2021-I2M-1-010)
中央高水平医院临床科研业务费项目(2023-GSP-RC-19)
出版年
2024
NETL
NSTL
万方数据