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冠状动脉粥样硬化病变快速进展的研究现状及进展

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随着影像学技术的普及与发展,冠状动脉粥样硬化病变快速进展的现象逐渐引起重视,其涉及医源性损伤、斑块破裂-愈合循环、炎症等多种病理生理机制,与心血管事件发生风险增加相关.斑块形态学特征、糖脂代谢指标和炎症因子对病变快速进展具有一定预测价值.降脂治疗是目前延缓病变快速进展的主要方法,新的有效靶点仍在研究中.目前针对病变快速进展的研究相对缺乏,本文拟就冠状动脉粥样硬化病变快速进展的病理生理机制、预测因素、评价方法与干预措施分别进行综述,以期为临床实践提供参考.
Research Status and Progress on Rapid Progression of Coronary Atherosclerosis
With the popularization and development of modern imaging techniques,a phenomenon of rapid progression of coronary atherosclerosis with increasing risk of cardiovascular events has attracted more attention.Rapid progression of coronary atherosclerosis is related to a variety of pathophysiological mechanisms,such as iatrogenic injury,subclinical cycle of plaque rupture and healing,inflammation and so on.Predictive value of plaque morphological features,glycolipid-related metabolites and inflammatory factors for rapid progression of coronary atherosclerosis has been intensively studied.Lipid-lowering therapy is currently the main method to hinder the rapid plaque progression,and new effective therapeutic targets are still under investigations.In this review,we summarize the pathophysiology,predictors,evaluation methods and treatments of rapid progression of coronary atherosclerosis,aiming to provide useful information for the clinical practice.

coronary atherosclerosisrapid progression of coronary atherosclerosisaccelerated atherosclerosiscoronary artery disease

江瑶、张茵、耿荧阳、张楚捷、张晗、许晶晶、宋莹、崔成、朱佩、宋雷

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中国医学科学院 北京协和医学院 国家心血管病中心 阜外医院 心内科,北京 100037

冠状动脉粥样硬化 冠状动脉粥样硬化病变快速进展 加速性动脉粥样硬化 冠心病

2024

中国循环杂志
中国医学科学院

中国循环杂志

CSTPCD北大核心
影响因子:2.803
ISSN:1000-3614
年,卷(期):2024.39(12)