Research Advances in Molecular Mechanism of Cardiac Fibrosis Related to Atrial Fibrillation
The pathogenesis of atrial fibrillation is complex and individualized.Cardiac fibrosis plays an important role in the occurrence,recurrence,complications,and treatment of atrial fibrillation by participating in cardiac structural and electrical remodeling.Studies have shown that cardiac fibrosis is associated with extensive neurohumoral regulation and complicated molecular interactions and is regulated by multiple signal pathways.Therefore,cardiac fibrosis is expected to be an effective and promising intervention target for atrial fibrillation.This review article summarizes the current intracellular and extracellular molecular mechanisms of cardiac fibrosis in atrial fibrillation aiming to provide new ideas for the prevention and treatment of atrial fibrillation.
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