双相Ⅰ型障碍和双相Ⅱ型患者人口学和临床特征的比较
Comparison of demographic and clinical characteristics of bipolar Ⅰ disorder and bipolar Ⅱ disorder
周莉 1谢依玲 2张婷婷 3黄悦勤 3周亮 4刘燕 5刘波 6章杰 7龚元东 8李中才 9李弼 10李志鹏 1曾庆园 11沈宗霖 2陈文明 11刘肇瑞 3卢瑾2
作者信息
- 1. 云南省精神病医院,昆明 650224
- 2. 昆明医科大学第一附属医院精神科,昆明 650032
- 3. 北京大学第六医院,北京大学精神卫生研究所,国家卫生健康委员会精神卫生学重点实验室(北京大学),国家精神心理疾病临床医学研究中心(北京大学第六医院),北京 100083
- 4. 广州医科大学附属脑科医院,广州 510370
- 5. 济宁医学院,山东济宁 272013
- 6. 荆州市精神卫生中心,湖北荆州 434000
- 7. 中山市第三人民医院,中山市心理卫生中心,广东中山 528451
- 8. 山东省精神卫生中心,济南 250014
- 9. 楚雄州第二人民医院,云南楚雄 675000
- 10. 云南省玉溪市第二人民医院,云南玉溪 653100
- 11. 普洱市第二人民医院,云南普洱 665000
- 折叠
摘要
目的:比较双相Ⅰ型障碍和双相Ⅱ型障碍患者的人口学特征、临床特征、治疗特征和生理指标.方法:选取符合美国精神障碍诊断与统计手册第5版(DSM-5)双相障碍的患者381例,其中Ⅰ型302例(79.27％),Ⅱ型74例(19.42％),其他特定及相关障碍5例(1.31％).用自编临床资料访谈表收集人口学资料及临床特征数据.采用多因素logistic回归和多重线性回归分析方法进行因素分析.结果:与双相Ⅱ型障碍相比,双相Ⅰ型障碍患者更容易伴有精神病性特征(OR=5.75,95％CI:2.82～11.76),病程更长,接受重复经颅磁刺激治疗较多(OR=3.09,95％CI:1.02～9.35),尿酸、总胆固醇、高密度脂蛋白浓度更高,汉族更常见(OR=11.50,95％CI:1.76～75.30)、受教育程度更低(OR=10.22,95％CI:1.16～89.77),更少有精神病家族史(OR=2.34,95％CI:1.01～5.42).结论:双相Ⅰ型障碍和双相Ⅱ型障碍的人口学特征、临床特征、治疗情况和生理指标有差异,可为探讨双相障碍的发病机制提供线索.
Abstract
Objective:To compare demographic characteristics,clinical characteristics,therapeutic characteris-tics and physiological indicators of patients with bipolar Ⅰ disorder and bipolar Ⅱ disorder.Methods:A total of 381 patients with bipolar disorder(BD)diagnosed by the Diagnostic and Statistical Manual of Mental Disorders 5 th Edi-tion(DSM-5)were selected,including 302 patients with BD-Ⅰ(79.27％),74 patients with BD-Ⅱ(19.42％)and 5 patients with other specific and related disorders(1.31％).Demographic and clinical characteristics were collected with self-designed clinical information questionnaire.Multivariate logistic regression and multivariate linear regres-sion analysis were used for analysis.Results:Compared with patients with BD-Ⅱ,patients with BD-Ⅰ had more risk to have psychotic features(OR=5.75,95％CI:2.82-11.76),longer disease duration,and more repeated transcra-nial magnetic therapy(OR=3.09,95％CI:1.02-9.35),higher uric acid,total cholesterol and high-density lipo-protein.BD-Ⅰ in Han nationality was more common(OR=11.50,95％CI:1.76-75.30),and had lower education level(OR=10.22,95％CI:1.16-89.77),and less family history of psychosis(OR=2.34,95％CI:1.01-5.42).Conclusion:There are significant differences between BD-Ⅰ and BD-Ⅱ in demographic and clinical charac-teristics,treatment status,and physiological indicators,which could provide clues for exploring the pathogenesis of bipolar disorder.
关键词
双相Ⅰ型障碍/双相Ⅱ型障碍/临床特征/生理指标/治疗Key words
bipolar Ⅰ disorder/bipolar Ⅱ disorder/clinical characteristics/physiological indicators/treat-ment patterns引用本文复制引用
基金项目
国家重点研发计划(2017YFC0907800)
出版年
2024
国家科技期刊平台
NSTL
万方数据