Ventral pallidum and its relationship with relapse in alcohol-dependent patients
Objective:To investigate the volume change of ventral pallidum(VP)in alcohol-dependent pa-tients(ADPs)and whether the volume of VP is related to relapse.Methods:This study was a combination of cross-sectional and cohort study,which included 33 patients who met the diagnostic criteria for alcohol dependence syn-drome in the Diagnostic and Statistical Manual of Mental Disorders,Fourth Edition(DSM-Ⅳ).All the ADPs re-ceived clinical questionnaires within 14-28 days of alcohol withdrawal,including a semi-structured questionnaire,the Clinical Institute Withdrawal Assessment(CIWA)and Alcohol Use Disorders Identification Test(AUDIT).The volumes of VP were measured by using magnetic resonance imaging(MRI).A self-made follow-up question-naire was used to assess post treatment outcome.The ADPs were divided into relapse group and abstinence group within the 6-month follow-up.The VP volume were compared between the ADPs and normal controls,and relapse group and abstinence group.Results:The VP volumes were smaller in the ADPs than in the normal controls[(1749±492)mm3 vs.(2116±189)mm3,P＜0.05].The VP volumes were larger in the relapse group than in the absti-nence group[(1956±452)mm3 vs.(1555±458)mm3,P＜0.05].Conclusion:It suggests that the ventral pallidum in alcohol-dependent patients may participate in pathological reward circuit function,which is related to relapse.
万方数据
维普
