目的:运用meta分析评价认知联合运动干预对轻度认知障碍的效果.方法:检索中国知网、PubMed、Web of Science、Cochrane和Embase等5个数据库,纳入采用认知联合运动疗法治疗轻度认知障碍的随机对照研究,运用Stata15.0软件进行统计分析,评价总体认知功能、记忆力和执行功能或注意力的效果,并进行亚组分析.结果:共纳入28篇文献,包括2 796名研究对象.结果显示,联合干预对总体认知功能(SMD=0.68,95％CI:0.39～0.97)、记忆力(SMD=0.35,95％CI:0.01～0.68)以及执行功能或注意力(SMD=-0.28,95％CI:-0.51～-0.05])的干预效果均优于对照组.亚组分析结果表明,联合干预对于研究对象上述认知功能的干预效果受到干预模式、对照类型、是否有其他干预措施和干预频率的影响.结论:认知联合运动干预可以有效改善轻度认知障碍.
Abstract
Objective:To evaluate the effect of combined cognitive and physical intervention on mild cogni-tive impairment(MCI)using meta-analysis.Methods:Five databases including CNKI,PubMed,Web of Science,Cochrane and Embase were retrieved.Randomized Control Trials containing the combined cognitive and physical therapies on MCI were included.Statistical analysis,including the evaluation of the effects on global cognition,memory and executive function or attention,as well as the subgroup analysis were conducted using Stata 15.0.Results:A total of 28 articles was eventually included,with 2 796 participants.Results showed that the effec-tiveness of combined intervention on global cognitive function(SMD=0.68,95％CI:0.39-0.97),memory(SMD=0.35,95％CI:0.01-0.68)as well as executive function or attention(SMD=-0.28,95％CI:-0.51--0.05)were significantly better than the control group.Subgroup analysis indicated that the effects of combined intervention on the above domains of cognitive function among the participants were affected by the intervention mode,control type,whether there were other interventions and intervention frequency.Conclusion:Combined cogni-tive and physical intervention could effectively improve mild cognitive impairment.
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