目的:探索重复经颅磁刺激对精神分裂症患者认知功能的干预效果.方法:检索中国知网、万方、维普、PubMed、Web of science、Cochrane、Embase数据库有关重复经颅磁刺激干预精神分裂症患者认知功能的随机对照试验,根据Cochrane系统审查手册评估纳入研究的质量.通过Revman5.3软件计算效应量及异质性.结果:共纳入31项(2421例)随机对照试验.Meta分析结果显示,rTMS能改善精神分裂症患者的认知功能(SMD=0.73).亚组分析显示,刺激强度≤100％RMT、刺激频率为1Hz、刺激时间为≥20 min、刺激周期为4周的rTMS能改善精神分裂症患者的认知功能效果更好(SMD=0.74、0.94、0.91、0.92),对病程为5～10年患者的认知功能的改善效果更好(SMD=0.91).结论:重复经颅磁刺激可以有效改善精神分裂症患者的认知功能,建议在临床中将参数设置为刺激强度≤100％RMT、刺激频率为1Hz、刺激时间≥20 min、干预周期为4周.
A meta-analysis of effects of repetitive transcranial magnetic stimulation on cognitive function intervention in patients with schizophrenia
Objective:To explore the intervention effects of repetitive transcranial magnetic stimulation on cognitive function of schizophrenia patients with methods using meta-analysis.Methods:CNKI,Wanfang Data,VIP,PubMed,Web of Science,the Cochrane Library and Embase were searched for randomized controlled trials of repetitive transcranial magnetic stimulation on cognitive function in schizophrenia.Quality assessment was per-formed with the Cochrane Handbook for Systematic Reviews.Effect sizes and heterogeneity were assessed using RevMan 5.3.Results:A total of 31 randomized controlled trials(2 421 patients)were included in this study.Meta-analysis showed that rTMS improved cognitive function in schizophrenia patients(SMD=0.73).Subgroup analyses showed that intervention intensity was less than or equal to 100％RMT,the intervention frequency was 1 Hz,the intervention time was lasted at least 20 min/time,and the intervention period was four weeks,the effect of rTMS was better.Subgroup analyses showed that rTMS was more effective in improving for patients with durations of 5 to 10 years.Conclusion:rTMS has more significant improvement effects on cognitive function in schizophrenia pa-tients.It is recommended to set the intervention intensity 100％RMT,the intervention frequency of 1 Hz,the in-tervention time ≥20 min,and the intervention period of 4 weeks in the clinic.
repetitive transcranial magnetic stimulationschizophreniacognitionmeta-analysis
万方数据
维普
