目的:采用meta分析评价θ短阵快速脉冲刺激(TBS)对精神分裂症的疗效及安全性。方法:检索中国知网、万方、维普、中国生物医学、Web of science、PubMed、Embase和Cochrane Library数据库自建库至2022年12月关于TBS治疗精神分裂症的随机对照试验(RCT)，主要研究指标为阳性与阴性量表(PANSS)，由2位评审员对纳入文献进行风险质量评估，并用RevMan5。3进行meta分析。结果:共纳入13个RCT，641例患者。Meta分析结果显示，干预时间≥2周、以左侧前额叶背外侧皮质为靶点的TBS 更能降低 PANSS 总分(WMD=-4。63，95％CI:-5。75～-3。51，P＜0。001)、阳性症状得分(WMD=-1。13，95％CI:-2。00～-0。26，P＜0。05)、阴性症状得分(WMD=-2。51，95％CI:-2。77～-1。53，P＜0。001)和一般精神病理症状得分(WMD=-1。20，95％CI:-1。80～-0。60，P＜0。0001)。TBS不良反应有头晕等，无严重不良事件报告。结论:TBS安全性较好，2周及以上和左侧前额叶背外侧皮质靶点的刺激可能对精神分裂症患者的精神症状改善更明显。
Meta-analysis of θ short array rapid pulse stimulation in treatment of schizophrenia
Objective:To evaluate the efficacy and safety of θ short burst rapid pulse stimulation(TBS)in treating schizophrenia by meta-analysis.Methods:Randomized controlled trials(RCTS)on TBS in the treatment of schizophrenia were searched from CNKI,Wanfang,VIP,China Biomedicine,Web of science,PubMed,Embase and Cochrane Library databases to December 2022.The main study indicator was the Positive and Negative Symptoms Scale(PANSS).Risk quality assessment of the included literatures was performed by two reviewers and statistical analysis was performed using RevMan5.3.Results:A total of 13 RCTS with 641 patients were included.Meta-anal-ysis showed that TBS targeting the left dorsolateral prefrontal cortex(DLPFC)with intervention duration longer than 2 weeks decreased the PANSS total scores(WMD=-4.63,95％CI:-5.75--3.51,P＜0.001),positive symptom scores(WMD=-1.13,95％CI:-2.00--0.26,P＜0.05),negative symptom scores(WMD=-2.51,95％CI:-2.77--1.53,P＜0.001)and general psychopathological symptom scores(WMD=-1.20,95％CI:-1.80--0.60,P＜0.001).The adverse reactions of TBS included dizziness,and no serious adverse e-vents were reported.Conclusion:TBS has high safety,and stimulation of left dorsolateral prefrontal cortex targets for more than 2 weeks could effectively improve psychiatric symptoms in patients with schizophrenia.
schizophreniaθ Short array fast pulse stimulationmeta-analysis
万方数据
维普
