DNA methylation is the common base modification in the eukaryotic genome and is an important epigenetic mechanism. Methylation at the five-carbon of cytosine is a reversible process that can directly influence gene activity and the reaction is catalyzed by a family of DNA methyltransferases(DNMTs). DNA methylation is essential for normal mammals development and plays an important role in the affects a wide range of essential biological processes, and it includes silencing of transposable elements, inactivation of genes, maintenance of chromosomal integrity, X chromosome inactivation.and transcriptional regulation of a large number of genes and so on.
DNA methylationDNA methyltransferasesepigenetic0silencing
国家科技期刊平台
NSTL
万方数据
维普
