Research Progress on the Effect of Robo2 Gene on Melanin Formation
Melanin is a kind of biological pigment,which plays an important role in antioxidant,temperature regulation and radiation protection.Although it is not necessary for biological growth and development,its existence can improve the survival and competitiveness of organisms.Animal melanin is synthesized and stored by the organelle melanosomes in melanocytes.Animal melanocytes are mainly neural crest cells that migrate and differentiate along the dorsal path.Roundabout guidance receptor 2(Robo2)gene is a member of Robo,a family of axon guidance molecules,and is the main receptor for guiding dorsal axon guidance.By introducing the formation and synthesis pathway of animal melanin,the author briefly describes the source and function of Robo2 gene,and describes the role of Robo2 gene in the direction of neuronal growth cone movement,the expression of microphthalmia associated transcription factor(MITF)and axonal development during melanin formation,and complements the mechanism of melanin synthesis,This study provides a theoretical basis for finding the major genes affecting melanin synthesis and revealing the mechanism of melanin synthesis.However,there are still many unsolved mysteries about the specific mechanism and regulatory pathway of Robo2 gene in melanin formation,which need further research to reveal.
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