Study on Ursolic Acid Mediated Hypoxia Inducible Factor 1α Potential Mechanisms for Alleviating the Occurrence of Woody Breast
The lesion rate of woody breast is as high as 20％in fast-growing White feather broiler,it seriously reduces consumers'desire to buy,and is not conducive to post-processing,resulting in relatively high economic losses.Hypoxia is an important cause of woody breast,and hypoxia inducible factor 1α(HIF-1α)is a key factor in regulating cell function under hypoxia.Ursolic acid has the effects of anti-oxidation,anti-inflammatory and regulating glucose metabolism,and can regulate the expression of HIF-1α through adenylate-activated protein kinase(AMPK)and phosphatidylinositol kinase-3 kinase-protein kinase B(PI3K/Akt)signaling pathways.Therefore,the author reviews the pathogenesis of woody breast caused by hypoxia and how HIF-1α mediated glucose metabolism,oxidative stress and inflammatory responses are regulated by ursolic acid,and further analyzes the potential mechanism of ursolic acid regulating HIF-1α to alleviate the occurrence of woody breast through AMPK,PI3K/Akt and other signaling pathways.
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维普
