猪繁殖与呼吸综合征病毒(Porcine reproductive and respiratory syndrome virus,PRRSV)感染可引起母猪繁殖障碍、仔猪呼吸道疾病及公猪精液质量下降,给世界养猪业造成了巨大的经济损失.PRRSV不能自主复制,其生命周期的各个阶段均依赖于宿主的代谢系统.宿主细胞也可调节其代谢过程,以防止PRRSV复制和维持其正常生理功能.脂质代谢和糖代谢在PRRSV感染中均扮演了重要角色,PRRSV作为一种囊膜病毒对脂质代谢系统的依赖性较其他代谢系统更强.脂质参与了 PRRSV生命周期的各个阶段,包括吸附、进入、复制、组装和释放,此外还与细胞炎症、免疫和凋亡有关.糖代谢也可干扰PRRSV的生命活动,从而促进或抑制PRRSV复制.文章综述了脂质代谢中脂肪酸、胆固醇、磷脂、脂滴和脂筏以及糖代谢中糖酵解和三羧酸循环在PRRSV感染宿主细胞中的作用,以期为阐明PRRSV的致病机制以及疫苗和抗PRRSV药物的研发提供基本理论依据.
Research Progress on the Role of Lipid Metabolism and Glucose Metabolism in PRRSV-infected Host Cells
Porcine reproductive and respiratory syndrome virus(PRRSV)infection is known to cause reproductive disorders in sows,respiratory disease in piglets,and reduce semen quality in boars,resulting in significant economic losses to the global pig industry.PRRSV is unable to replicate on its own and relies on the host metabolic system for all stages of its life cycle.Host cells,in turn,regulate their metabolic processes to hinder PRRSV replication and maintain their normal physiological functions.Both lipid metabolism and glucose metabolism play crucial roles in PRRSV infection.As an enveloped virus,PRRSV is particularly reliant on lipid metabolism systems.Lipids are involved in various stages of the PRRSV life cycle,including adsorption,entry,replication,assembly and release,it is also associated with cellular inflammation,immunity and apoptosis.Glucose metabolism can also interfere with PRRSV life activities,thereby promoting or inhibiting PRRSV replication.The roles of fatty acids,cholesterol,phospholipids,lipid droplets and lipid rafts in lipid metabolism are reviewed,along with the involvement of glycolysis and the tricarboxylic acid cycle in glucose metabolism in PRRSV-infected host cells,so to provide a theoretical basis for elucidating the pathogenic mechanism of PRRSV and contribute to the development of vaccines and anti-PRRSV drugs.
Porcine reproductive and respiratory syndrome virus(PRRSV)host cellslipid metabolismglucose metabolism
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