Observation on the Anesthetic Effect of Two Administration Regimens of Zoletil Combined with Dexmedetomidine on Bama Miniature Pig
[Objective]This experiment was aimed to explore the effect of different zoletil combined with dexmedetomidine on the anesthetic effect of Bama miniature pigs.[Method]Eight Bama miniature pigs were randomly divided into intravenous injection(IV)group and intramuscular injection(IM)group,and the anesthesia interval was 14 days.Group IV received zoletil 3.3 mg/kg+dexmedetomidine 8 μg/kg intravenously at the ear edge.In group IM,zoletil 4.6 mg/kg+dexmedetomidine 11.2 μg/kg was injected into the muscles of the neck behind the ear.The period of anesthesia,anesthetic effect,biological reflex and physiological indexes of Bama miniature pigs were monitored during anesthesia.[Result]The results showed that the induction time,maintenance time and recovery time of anesthesia in group IV were 3.75,85.75 and 30.25 min,respectively.The induction time,maintenance time and recovery time of anesthesia in group IM were 7.13,107.00 and 41.00 min,respectively.Groups IV and IM could maintain surgical anesthesia for 50 and 65 min,respectively.The anesthesia effect score in group IM was significantly higher than that in group IV during 80-110 min(P＜0.05).During anesthesia,body temperature decreased.Heart rate and blood oxygen saturation decreased first and then increased.Respiratory rate,systolic pressure,stretch pressure and mean arterial pressure increased first and then decreased.Respiratory rate in group IM was significantly higher than that in group IV during 50-80 min(P＜0.05).The systolic blood pressure in group IM was lower than that in group IV during 10-15 min(P＜0.05).The total inhibition time of biological reflex in groups IV and IM were 45 and 50 min,respectively.[Conclusion]Zoletil combined with dexmedetomidine had a good anesthesia effect on Bama miniature pigs,with rapid induction,long maintenance time,stable recovery,and minimal impact on physiological indicators and biological reflexes.Among them,group IM anesthesia plan was more suitable for clinical surgery and scientific research teaching than group IV.
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