Research Progress on the Regulation of Autophagy by Acetylation Modification
Autophagy is a process in which cells degrade their own contents through the function of lysosomes.Mutations in autophagy-related processes can lead to serious human diseases,such as cancer,cardiovascular diseases,neurodegenerative diseases,metabolic diseases,lung diseases and kidney diseases.Autophagy can combine some biochemical reactions of the body to form a dynamic circulatory system,which can eliminate harmful substances and provide new energy for cell renewal and maintaining balance in the body.Therefore,autophagy plays an important role in the physiological and pathological processes of the body.In recent years,some medical and animal physiological and pathological studies have pointed out that acetylation modification plays a key role in regulating cell autophagy.As a kind of modification methods in protein post-translational modification,acetylation is a reversible post-translational modification mediated by acetyltransferase and deacetylase.Among them,acetyltransferase transfers the acetyl group of acetyl coenzyme A to the amino acid residue of the substrate protein,and the removal of acetyl group is completed by deacetylase.Acetylation modification often occurs on the histone lysine ε-amino group and the N-terminal a-amino group of non-histone proteins.The authors describe the effect of acetylation modification on cell autophagy from the level of histone and non-histone acetylation modification,in order to provide reference and direction for the further study of the role of acetylation modification in cell autophagy and its therapeutic effect on various diseases.
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