Research Progress on Regulation of Thermogenic Adipose Tissue by m6A Methylation Modification
Excessive deposition of adipose tissue can lead to obesity and related metabolic diseases,and also directly affect the productivity and product quality of livestock and poultry.Therefore,how to regulate adipose tissue deposition is of great significance for safeguarding human health,increasing animal production performance and improving the quality of animal products.The thermogenic function of adipose tissue has become an area of great concern,which can regulate the body's thermogenesis through the consumption of glucose,fatty acids,and other energy substances,so as to achieve the purpose of maintaining the energy balance of the body.N6-methyladenosine(m6A)modification,as a major epigenetic mark on RNA molecules,is activated in brown adipose tissue,adipose tissue browning and thermogenesis.The author outlines the thermogenesis of adipose tissue and mRNA m6A-related modification proteins,and focuses on the regulation of energy metabolism in thermogenic adipose tissue by mRNA m6A methylation modification,which is crucial for energy homeostasis,thermogenic adipose activation and metabolic diseases,so as to lay a foundation for the study of the specific thermogenic mechanism of thermogenic fat,and provide new ideas for the precise targeting and regulation of thermogenic mechanism of animal fat,and thus the regulation of animal production performance and product quality.
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