Regulation of Metabolism by High Concentration of Lanthanum in Caenorhabditis elegans
In recent years,the wide application of rare earth elements(REEs)has led to the release of immea-surable rare earth metals into the external environment,which has posed a great threat to the ecological environ-ment and even human health.In particular,the concentration of REEs in the environment has seriously exceed-ed the standard near the mining area rich in REEs.However,current studies mainly focus on the effects of low concentrations of REEs on organisms,and there are few studies on the toxicity of high concentrations of REEs.In order to supplement the research on the biological effects of high concentrations of REEs,we took Caenorhab-ditis elegans(C.elegans)as a model organism,selected lanthanum(La),a rare earth element with abundant and widely used,as the experimental object,and combined with metabolomics methods to explore the physiolog-ical and related metabolic changes of nematodes caused by high concentrations of La from the endogenous small molecule level.The results show that La is accumulated in a concentration-dependent manner in C.elegans.The lifespan of worms is negatively affected by Lanthanum at high concentrations.There is also a positive correlation be-tween La concentration and toxicity.In addition,Lanthanum exposure at high concentration also causes metabolic disorders in C.elegans,resulting in the disorders of many physiological functions including immune response.
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