Seroprevalence of the specific antibody against Toxoplasma gondii among patients with hematological diseases
Objective To investigate the seroprevalence of Toxoplasma gondii infections among patients with hematological diseases,so as to provide insights into improving the prognosis and quality of life among patients with hematological diseases.Methods A total of 240 patients with hematological diseases(including 170 patients with hematological tumors and 70 patients with non-tumor hematological diseases)admitted to The Affiliated Hospital of Putian University during the period from January 1,2021 through October 10,2023 and 500 healthy volunteers in the hospital during the same period were enrolled.Subjects'demo-graphics and serum samples were collected,and serum specific IgG and IgM antibodies against T.gondii were detected using the chemiluminescence assay,with any of a positive IgG or IgM antibody defined as a positive T.gondii infection.The seropreva-lence of specific IgG and IgM antibodies against T.gondii was compared between patients with hematological diseases and healthy volunteers.Results The mean age(F = 2.034,P>0.05)and gender distribution(χ2 = 0.462,P>0.05)were compara-ble among patients with hematological tumors,patients with non-tumor hematological diseases and healthy volunteers,and there was no significant difference in the proportion of history of cat or dog contacts between patients with hematological diseases and healthy volunteers(χ2 = 0,P>0.05).The seroprevalence of anti-T.gondii antibody was significantly higher among patients with hematological diseases than among healthy volunteers(15.8%vs.0.6%;χ2 = 71.902,P<0.01),and there was a significant differ-ence in the seroprevalence of anti-T.gondii antibody among patients with hematological tumors(18.2%),patients with non-tumor hematological diseases(10.0%)and healthy volunteers(χ2 = 78.327,P<0.01).The seroprevalence of anti-T.gondii antibody was significantly higher among patients with hematological tumors and non-tumor hematological diseases than among healthy volun-teers(both P values<0.05),while no significant difference was seen in the seroprevalence of anti-T.gondii antibody between pa-tients with hematological tumors and non-tumor hematological diseases(P>0.05).In addition,the proportion of history of cat or dog contacts was significantly higher among patients with hematological diseases that were positive for serum anti-T.gondii anti-body than among those negative for serum anti-T.gondii antibody(21.1%vs.5.4%;χ2 = 8.653,P<0.05).Conclusions There is a high seroprevalene rate of T.gondii infections among hematological diseases,which is significantly greater than that among healthy volunteers.
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