抗菌肽LL-37抗寄生虫活性研究进展
Progress of researches on the antiparasitic activity of antimicrobial peptide LL-37
楼俊超 1何小芹1
作者信息
- 1. 南京医科大学公共卫生学院(江苏南京 211166);国家卫生健康委员会寄生虫病预防与控制技术重点实验室、江苏省寄生虫与媒介控制技术重点实验室、江苏省血吸虫病防治研究所(江苏无锡 214064)
- 折叠
摘要
由原虫、蠕虫感染导致的寄生虫病在全球范围内广泛流行,尤其是在热带和亚热带地区,对儿童和成人生命健康均造成威胁.抗寄生虫药的长期使用导致寄生虫对药物敏感性下降甚至出现耐药性.研究表明抗菌肽可抑制寄生虫生长发育,具有潜在抗寄生虫价值,其中LL-37作为组织蛋白酶抑制素(cathelicidin)家族中唯一的人源抗菌肽被广泛研究.本文综述了LL-37抗寄生虫作用的研究进展,并对其作为抗寄生虫药物的候选资源的应用前景进行了探讨.
Abstract
Parasitic diseases caused by protozoan and helminth infections are still widespread across the world,notably in trop-ical and subtropical areas,which threaten the children and adult health.Long-term use of anti-parasitic drugs may result in re-duced drug susceptibility and even drug resistance.Antimicrobial peptides have been demonstrated to inhibit parasite growth and development,which has potential antiparasitic values.LL-37,the only human antimicrobial peptide in the cathelicidin fami-ly,has been widely investigated.This paper reviews the progress of researches on the antiparasitic activity of LL-37,and discuss-es the prospects of LL-37 in the research of parasites.
关键词
寄生虫/人源抗菌肽/LL-37/作用机制Key words
Parasite/Human antimicrobial peptide/LL-37/Mechanism of action引用本文复制引用
出版年
2024
NETL
NSTL
万方数据