Latest advances in the development of tuberculosis vaccines in global clini-cal trials:a review
Tuberculosis(TB)remains one of the biggest infectious killers worldwide.Vaccine is the most satisfactory tool for prevention of TB;however,Bacillus Calmette-Guérin(BCG),the widely used vaccine in clinical for the prevention of TB,has limi-tations in protective effects.Development of novel TB vaccines is therefore of urgent need.Currently,there are 15 novel TB vac-cine candidates in clinical trials,including live-attenuated vaccines,inactivated vaccines,subunit vaccines and viral-vectored vaccines,which open the door for the ultimate target of the End TB Strategy.This review summarizes the latest advances in the development of TB vaccines in global clinical trials,so as to provide insights into TB control.
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