Auxiliary diagnosis of visceral leishmaniasis with metagenomic next-genera-tion sequencing:a case report
This case report summarizes the experience from diagnosis and treatment of a patient with repeated high fever,hep-atosplenomegaly and pancytopenia.Following exclusion of bacterial,viral,fungal infections and hematological diseases,metage-nomic next-generation sequencing of the patient's peripheral blood revealed Leishmania infantum infection,and rK39 rapid diag-nostic test showed positive for anti-Leishmania antibody,while microscopic examination of bone marrow smears identified Leish-mania amastigotes.Therefore,the case was definitively diagnosed as visceral leishmaniasis,and given anti-infective treatment with sodium antimony gluconate and hormone,hepatoprotection,elevation of white blood cell counts and personalized nursing.Then,the case was cured and discharged from hospital.Metagenomic next-generation sequencing is of great value in etiological detection of fever patients with unknown causes,which deserves widespread clinical applications.
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