疟疾是世界上危害最严重的蚊媒传染病之一.近年来,全球疟疾防控进展迟缓,重要原因之一是来自疟疾病原疟原虫和传播媒介按蚊的生物学挑战.本文针对抗疟药耐药性、疟疾快速诊断试纸条靶标恶性疟原虫富组氨酸蛋白2/3(Plasmodium falci-parum histidine-rich protein 2/3,Pfhrp2/3)基因缺失、媒介杀虫剂抗性及按蚊入侵等生物学挑战进行概述,从而为当前疟疾及其媒介相关研究提供参考,亦为疟疾控制和消除策略的制订和调整提供科学依据.
While the priest climbs a post,the devil climbs ten:major biological threats from parasite and vector to malaria control and elimination
Malaria is one of the most serious mosquito-borne infectious diseases in the world.The global malaria control prog-ress has stalled in recent years,which is largely due to the biological threats from the malaria pathogen Plasmodium and the vec-tor Anopheles mosquitoes.This article provides an overview of biological threats to global malaria elimination,including antima-larial drug resistance,deletions in the malaria rapid diagnostic test target P.falciparum histidine-rich protein 2/3(Pfhrp2/3)genes,vector insecticide resistance and emergence of invasive vector species,so as to provide insights into malaria and vector re-search and the formulation and adjustment of the malaria control and elimination strategy.
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