道高一尺,魔高一丈:疟疾防控面临的病原学和媒介生物学挑战
While the priest climbs a post,the devil climbs ten:major biological threats from parasite and vector to malaria control and elimination
俞心愉 1曹俊2
作者信息
- 1. 国家卫生健康委员会寄生虫病预防与控制技术重点实验室、江苏省寄生虫与媒介控制技术重点实验室、江苏省血吸虫病防治研究所(江苏无锡 214064)
- 2. 国家卫生健康委员会寄生虫病预防与控制技术重点实验室、江苏省寄生虫与媒介控制技术重点实验室、江苏省血吸虫病防治研究所(江苏无锡 214064);南京医科大学公共卫生学院全球健康中心(江苏南京 211166)
- 折叠
摘要
疟疾是世界上危害最严重的蚊媒传染病之一.近年来,全球疟疾防控进展迟缓,重要原因之一是来自疟疾病原疟原虫和传播媒介按蚊的生物学挑战.本文针对抗疟药耐药性、疟疾快速诊断试纸条靶标恶性疟原虫富组氨酸蛋白2/3(Plasmodium falci-parum histidine-rich protein 2/3,Pfhrp2/3)基因缺失、媒介杀虫剂抗性及按蚊入侵等生物学挑战进行概述,从而为当前疟疾及其媒介相关研究提供参考,亦为疟疾控制和消除策略的制订和调整提供科学依据.
Abstract
Malaria is one of the most serious mosquito-borne infectious diseases in the world.The global malaria control prog-ress has stalled in recent years,which is largely due to the biological threats from the malaria pathogen Plasmodium and the vec-tor Anopheles mosquitoes.This article provides an overview of biological threats to global malaria elimination,including antima-larial drug resistance,deletions in the malaria rapid diagnostic test target P.falciparum histidine-rich protein 2/3(Pfhrp2/3)genes,vector insecticide resistance and emergence of invasive vector species,so as to provide insights into malaria and vector re-search and the formulation and adjustment of the malaria control and elimination strategy.
关键词
疟疾/消除/疟原虫/按蚊/生物学挑战Key words
Malaria/Elimination/Plasmodium/Anopheles/Biological threat引用本文复制引用
基金项目
江苏省科教能力提升工程(ZDXYS202207)
出版年
2024
NETL
NSTL
万方数据