细胞焦亡与慢性心力衰竭的研究进展
The role of pyroptosis in chronic heart failure
潘嘉曦 1钟江华1
作者信息
- 1. 570208 海南省海口市,中南大学湘雅医学院附属海口医院心内科
- 折叠
摘要
焦亡是一种伴有炎症反应的程序性细胞死亡,其特征是质膜上膜孔的形成、促炎因子和细胞内容物的释放和细胞肿胀与破裂.最近的研究表明,焦亡与慢性心力衰竭(CHF)密切相关,因此,通过抑制焦亡相关的靶点来改善慢性心力衰竭具有重要的研究意义.本文综述了焦亡的信号通路和焦亡在慢性心力衰竭进展中的作用以及与焦亡相关的治疗靶点.
Abstract
Pyroptosis is a type of programmed cell death accompanied by an inflammatory,whose features are the formation of membrane pores on the cytoplasmic membrane,release of pro-inflammatory factors and cell contents,and swelling and rapid rupture of cells.Recent studies have suggested that pyroptosis is closely related with chronic heart failure(CHF),therefore,targeting pyroptosis has a good prospect in alleviating CHF.This paper reviews signaling pathways of pyroptosis and the role of pyroptosis in CHF as well as therapeutic targets associated with pyroptosis.
关键词
细胞焦亡/慢性心力衰竭/信号通路Key words
Pyroptosis/Chronic heart failure/Signaling pathway引用本文复制引用
基金项目
海南省重点研发计划(社会发展)项目(ZDYD2019134)
出版年
2024
NETL
NSTL
维普
万方数据