沙库巴曲-缬沙坦治疗心力衰竭的临床应用探究
Clinical application of sacubitril valsartan in the treatment of heart failure
王天蕴 1李芃瑾 1沈浩然 1顾逸淳 1毛路 2陈艾东1
作者信息
- 1. 211166 江苏省南京市,南京医科大学心血管病靶向干预重点实验室
- 2. 东南大学附属中大医院心脑血管病科
- 折叠
摘要
沙库巴曲-缬沙坦具有抗纤维化、减轻心肌肥厚和减少细胞凋亡作用,是一种可以显著降低心力衰竭(HF)患者病死率、住院和再住院率的药物.我国只有一小部分患者接受了沙库巴曲-缬沙坦的治疗,阻碍本药临床应用的主要障碍可能是医生对其机制、安全性和临床优势不够了解和对传统依那普利治疗的执念.本综述系统回顾了沙库巴曲-缬沙坦在治疗HF中所证实的益处,旨在为其对HF的治疗提供临床指导和关键的理论依据,有望成为临床医生重要的治疗参考.
Abstract
Sacubitril valsartan has the anti-fibrotic,reducing myocardial hypertrophy and cell apoptosis effects.It is a drug that can significantly reduce the mortality,hospitalization and readmission rates in patients with heart failure(HF).Only a small proportion of patients in our country have received the treatment with sacubitril valsartan now,and the main obstacle to the clinical application of this drug may be doctors'insufficient understanding of its mechanism,safety and clinical advantages,as well as their obsession with traditional enalapril treatment.This article systematically reviews the proven benefits of sacubitril valsartan in the treatment of HF,aiming to provide clinical guidance and key theoretical basis for its treatment of HF,and to become an important treatment reference for clinical doctors.
关键词
沙库巴曲-缬沙坦/心力衰竭/临床指导/理论依据Key words
Sacubitril valsartan/Heart failure/Clinical guidance/Theoretical basis引用本文复制引用
基金项目
国家自然科学基金面上项目(31571168)
国家自然科学基金面上项目(81571246)
出版年
2024
NETL
NSTL
万方数据