Objective To explore the predictive value of systemic inflammatory response index(SIRI)and neutrophil/lymphocyte ratio(NLR)for in-hospital death in patients with acute myocardial infarction(AMI).Methods The retrospective study included 2694 patients with AMI who were admitted to the cardiology unit of Xuanwu Hospital of Capital Medical University in January 2017 to December 2022.By the ROC curve analyzing,the optimal cut-off values for the in-hospital death of patients with AMI predicted by SIRI and NLR were obtained,which were 2.93 and 5.56 respectively.The patients were divided into groups according to the above optimal threshold values:the low value group(＜2.93,n=1960)and the high value group(≥2.93,n=734)according to SIRI,and the low value group(＜5.56,n=1886)and the high value group(≥5.56,n=808)according to NLR.The clinical baseline characteristics and the occurrence of major adverse cardiovascular events(MACEs)were compared between the two groups;and logistic regression was used to determine the predictive value of SIRI and NLR for the occurrence of MACEs in AMI patients.Results The in-hospital mortality of the low value groups both were 0.7％,and the mortality of high value groups was 5.4％in the high value group of SIRI and 4.8％in the high value group of NLR,which were significantly higher than those in the low value group(P＜0.05).In addition,the incidences of in-hospital death,ventricular tachycardia/ventricular fibrillation,atrial fibrillation,cardiac arrest,cardiac rupture and bleeding events in the high value groups of SIRI and NLR were significantly higher than in the low value groups(P＜0.05).Multivariate logistic regression analysis showed that SIRI(≥2.93 vs.＜2.93)(OR=2.780,95％CI 1.067-7.243,P=0.036)was also an independent risk factor for the in-hospital death of MACEs in AMI patients besides Killip grade,GRACE score,fasting blood glucose level and NT-proBNP(N-terminal-pro B-type Natriuretic Peptide).Conclusion SIRI can independently predict the risk of the in-hospital death in AMI patients.
维普
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