Objective To explore the current situation and related factors of AIDS discrimination among junior medical students in Jiangxi Province,so as to provide a reference for effective AIDS anti-discrimination intervention measures in medical colleges.Methods Using a convenience sampling approach,2 484 medical students were selected from five universities in Jiangxi Province from July to August 2023.An anonymous survey was conducted using a general information questionnaire,a AIDS knowledge ques-tionnaire,and the Chinese version of Zelaya's AIDS Stigma Scale.Independent sample t-tests and analysis of variance were carried out to analyze the level of AIDS discrimination among medical students with different characteristics.Multiple stepwise regression a-nalysis was performed to identify the related factors of AIDS discrimination.Results The total score of AIDS discrimination among medical students was(2.55±0.67).The dimension with the highest score was fear of contracting the disease(2.89±1.01).The re-sults of the multiple stepwise regression analysis showed that the factors related to AIDS discrimination included gender(β=-0.17),grade(β=-0.08),being an only child or not(β=-0.04),whether knowing about AIDS knowledge or not(β=0.22),willingness to use condoms during sexual activity(β=0.07),willingness to participate in school sexual health knowledge-based ac-tivities(β=0.05)and the perceived importance of self-health(β=0.11)(P<0.05).Conclusions AIDS discrimination is preva-lent among junior medical students in Jiangxi Province.Efforts should be undertaken to enhance humanistic education and relevant knowledge dissemination among junior medical students to reduce the level of AIDS discrimination.