Association between the ratio of dietary vitamin A to body weight and hypertension in children
Objective To explore the relationship between the ratio of dietary vitamin A(VitA)to body weight and hypertension among children,so as to provide a reference for blood pressure control through dietary nutritional interventions and childhood hyper-tension prevention.Methods Utilizing the baseline survey and follow-up sample data from the Healthy Children Cohort established in urban and rural areas of Chongqing from 2014 to 2019,structured quantitative dietary questionnaire and self-designed question-naire were used to investigate the information of dietary intake and socioeconomic characteristics of 15 279 children,as well as blood pressure,height,weight measurement.The ratio of dietary VitA to body weight was divided into four groups based on quar-tiles[≤P25(Ql),＞P25～P50(Q2),＞P50～P75(Q3),＞P75(Q4)].Generalized linear regression models and Logistic regression mod-els were used to analyze the correlation between ratio of dietary VitA to body weight with blood pressure levels and prevalence of hy-pertension.Results The results of the 2014 baseline survey indicated that,after adjusting for confounding factors such as demo-graphic indicators and nutritional intake,significant differences were observed in systolic blood pressure(SBP),diastolic blood pressure(DBP),and mean arterial pressure(MAP)among different groups categorized by the ratio of dietary VitA to body weight(F=157.57,44.71,95.92,P＜O.O1).The baseline ratio of dietary VitA to body weight in children exhibited a negative correlation with DBP,SBP and MAP at baseline and in 2019[baseline:β(95％CI)=-0.65(-0.89--0.42),-0.22(-0.42--0.01),-0.36(-0.56--0.16);2019:β(95％CI)=-0.77(-1.34--0.19),-0.62(-1.21--0.02),-0.77(-1.34--0.19),P＜0.05].Compared to Q 1 group,the risk of hypertension decreased among children in Q4 at baseline and follow-up in 2019[OR(95％CI)=0.63(0.49-0.81),0.18(0.08-0.42),P＜0.01].Conclusions The ratio of dietary VitA to body weight is significantly negatively correlated with blood pressure levels among children,and dietary VitA deficiency is an independent risk factor for hypertension among chil-dren.Measures should be taken to actively adjust children's dietary nutrition and reduce the risk of childhood hypertension.
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万方数据
