膳食维生素A和体重的比值与儿童高血压的相关性
Association between the ratio of dietary vitamin A to body weight and hypertension in children
程平 1任艳玲 2刘琴 2陈栏灵 2佟吉爽 2肖伦 3秦军 3李兴贵 1马军 1徐林 1史秀珍 1王莉 1万凌娟 1梁小华2
作者信息
- 1. 石棉县人民医院药剂科,四川雅安 625499
- 2. 重庆医科大学附属儿童医院儿研所/国家儿童健康与疾病临床医学研究中心/儿童发育疾病研究教育部重点实验室/儿科学重庆市重点实验室
- 3. 重庆市九龙坡区疾病预防与控制中心
- 折叠
摘要
目的 探讨膳食维生素A(VitA)和体重的比值与儿童高血压的相关性,为通过膳食营养干预改善儿童血压水平与降低儿童期高血压的患病风险提供参考.方法 利用2014-2019年在重庆城乡地区建立的健康儿童队列研究基线调查与随访样本资料,采用结构式定量膳食问卷和自行设计的调查表调查15 279名儿童膳食摄入量与社会经济学指标,测量血压、身高与体重等检测指标.儿童膳食VitA与体重的比值按照四分位数分为≤P25(Q1),＞P25～P50(Q2),＞P50～P75(Q3),＞P75(Q4)4组.采用广义线性回归模型与Logistic回归模型分析膳食VitA和体重的比值与血压水平及高血压患病率的相关性.结果 2014年基线调查结果表明,在校正人口统计学指标及营养摄入指标等混杂因素后,不同儿童膳食Vi-tA 摄入与体重比值组收缩压(SBP)、舒张压(DBP)、平均动脉压(MAP)的差异均有统计学意义(F值分别为157.57,44.71,95.92,P 值均＜0.05).2014 年儿童膳食 VitA 和体重的比值与 SBP[β 值(95％CI)=-0.65(-0.89～-0.42)]、DBP[β 值(95％CI)=-0.22(-0.42-0.01)]和 MAP[β值(95％CI)=-0.36(-0.56～-0.16)]均呈负相关(P值均＜0.05);与Q1组比较,Q4组中儿童高血压的患病风险降低[OR值(95％CI)=0.63(0.49～0.81),P＜0.01].2014年儿童基线膳食VitA和体重的比值与 2019年随访 SBP、DBP、MAP 均呈负相关[β值分别为-0.77(-1.34-0.19),-0.62(-1.21～-0.02),-0.77(-1.34～-0.19),P值均＜0.05];与Q1组相比,Q4组中的2019年儿童高血压患病风险也降低[OR值(95％CI)=0.18(0.08～0.42),P＜0.01].结论 膳食VitA和体重的比值与儿童血压水平呈负相关,膳食VitA缺乏为儿童高血压的独立危险因素.应采取措施积极调整儿童膳食营养,降低儿童期高血压的患病风险.
Abstract
Objective To explore the relationship between the ratio of dietary vitamin A(VitA)to body weight and hypertension among children,so as to provide a reference for blood pressure control through dietary nutritional interventions and childhood hyper-tension prevention.Methods Utilizing the baseline survey and follow-up sample data from the Healthy Children Cohort established in urban and rural areas of Chongqing from 2014 to 2019,structured quantitative dietary questionnaire and self-designed question-naire were used to investigate the information of dietary intake and socioeconomic characteristics of 15 279 children,as well as blood pressure,height,weight measurement.The ratio of dietary VitA to body weight was divided into four groups based on quar-tiles[≤P25(Ql),＞P25～P50(Q2),＞P50～P75(Q3),＞P75(Q4)].Generalized linear regression models and Logistic regression mod-els were used to analyze the correlation between ratio of dietary VitA to body weight with blood pressure levels and prevalence of hy-pertension.Results The results of the 2014 baseline survey indicated that,after adjusting for confounding factors such as demo-graphic indicators and nutritional intake,significant differences were observed in systolic blood pressure(SBP),diastolic blood pressure(DBP),and mean arterial pressure(MAP)among different groups categorized by the ratio of dietary VitA to body weight(F=157.57,44.71,95.92,P＜O.O1).The baseline ratio of dietary VitA to body weight in children exhibited a negative correlation with DBP,SBP and MAP at baseline and in 2019[baseline:β(95％CI)=-0.65(-0.89--0.42),-0.22(-0.42--0.01),-0.36(-0.56--0.16);2019:β(95％CI)=-0.77(-1.34--0.19),-0.62(-1.21--0.02),-0.77(-1.34--0.19),P＜0.05].Compared to Q 1 group,the risk of hypertension decreased among children in Q4 at baseline and follow-up in 2019[OR(95％CI)=0.63(0.49-0.81),0.18(0.08-0.42),P＜0.01].Conclusions The ratio of dietary VitA to body weight is significantly negatively correlated with blood pressure levels among children,and dietary VitA deficiency is an independent risk factor for hypertension among chil-dren.Measures should be taken to actively adjust children's dietary nutrition and reduce the risk of childhood hypertension.
关键词
膳食/维生素A/体重/高血压/回归分析/儿童Key words
Diet/Vitamin A/Body weight/Hypertension/Regression analysis/Child引用本文复制引用
基金项目
重庆市科学技术委员会重点课题项目(CSTC2021jscxgksb-N0001)
重庆医科大学未来医学青年创新团队项目(W0088)
重庆市科卫联合项目(2020FYYX060)
国家自然科学基金青年基金项目(81502826)
出版年
2024
NETL
NSTL
万方数据