创伤大学生言语流畅性任务的功能性近红外成像研究
Functional near infrared imaging of college students on speech fluency tasks in traumatized
郑敏晓 1朱冬梅 2魏强 2向念 3邱敏 3肖强 3李晓南 3张妍4
作者信息
- 1. 华中科技大学教育科学研究院,湖北武汉 430074;江汉大学教育学院
- 2. 江汉大学教育学院
- 3. 华中科技大学医院心理科
- 4. 华中科技大学教育科学研究院,湖北武汉 430074
- 折叠
摘要
目的 利用近红外脑功能成像技术(fNIRS)探究不同创伤大学生在言语流畅性任务中认知功能差异的大脑神经机制,为创伤后应激障碍(PTSD)的评估和诊断提供神经影像学支持.方法 于2020年9-11月,根据创伤后应激障碍症状自评量表(平民版)(PCL-C)得分,从华中科技大学入学新生中抽取51名完成言语流畅性任务,根据PCL-C≥38分选取创伤组21名,根据PCL-C＜38分选取对照组30名,同时用53通道的近红外光谱设备(fNIRS)收集其大脑血氧信号.采用Mann-Whitney U检验和t检验比较创伤组和对照组的氧合血红蛋白含量和PCL-C评分差异,采用Spearman相关分析大学生PTSD和氧合血红蛋白的相关性.结果 创伤组和对照组被试在PCL-C量表上的总平均分(46.38±6.96,25.57± 6.09)差异有统计学意义(t=11.33,P＜0.05).大学生个体左侧背外侧前额叶的氧合血红蛋白信号变化与PCL-C量表得分呈负相关(r=-0.37,P＜0.05).创伤组左侧背外侧前额叶通道6的氧合血红蛋白含量[0.19(-0.09,0.86)mmol/(L·mm)]低于对照组[0.79(0.37,1.47)mmol/(L·mm)](Z=2.16,P＜0.05).结论 大学生创伤程度与左侧背外侧前额叶氧合血红蛋白指标有相关性.未来或可利用fNIRS收集认知任务中左侧背外侧前额叶血氧信号,为大学生PTSD的鉴别提供影像学依据.
Abstract
Objective The study aims to explore the neural mechanism of cognitive differences in college students with posttrau-matic stress disorder under verbal fluency task based on functional near-infrared spectroscopy(fNIRS),so as to provide neuroimag-ing support for the evaluation,diagnosis and treatment of posttraumatic stress disorder(PTSD).Methods Posttaumatic Stress Dis-order Checklist-Combat(PCL-C)was used to screen the subjects,including 21 students in PTSD group(PCL-C ≥ 38)and 30 students in control group from September to Novenber in 2020.A 53-channel near-infrared spectroscopy device was used to collect cerebral blood oxygen signals under the verbal fluency task,and correlation analysis,Mann-Whitney U test and independent sample t test were performed on the results.Results The difference in the total average score of PCL-C Scale between PTSD group and the control group(46.38±6.96,25.57±6.09)was statistically significant(t=11.33,P＜0.05).Correlation analysis showed that Avg-HbO in left dorsolateral prefrontal lobe was negatively correlated with PCL-C Score(r=-0.37,P＜0.05).Mann-Whitney U test showed that in the left dorsolateral prefrontal lobe(Ch6),the Avg-HbO change in PTSD group[0.19(-0.09,0.86)mmol/(L· mm)]was significantly lower than the control group[0.79(0.37,1.47)mmol/(L mm)](Z=2.16,P＜0.05),which was statisti-cally significant.Conclusions The degree of PTSD was negatively correlated with the index of oxygenated hemoglobin in the left dorsolateral prefrontal lobe,and the oxygenated hemoglobin content in the PTSD group was lower than that in the normal group.In the future,fNIRS may be used to collect blood oxygen signals from the left dorsolateral prefrontal lobe in cognitive tasks to provide imaging evidence for the identification of PTSD.
关键词
言语/谱学,近红外线/精神卫生/应激障碍,创伤后/学生Key words
Speech/Spectroscopy,near-infrared/Mental health/Stress disorders,post-traumatic/Students引用本文复制引用
基金项目
江汉大学校级科研专项立项项目(第三批)(2023XYB21)
华中科技大学自主创新研究基金(2023WKFZZX109)
出版年
2024
NETL
NSTL
万方数据