Expression levels of serum biomarkers in adolescents with generalized anxiety disorder
Objective To investigate the expression levels of serum neuron-specific enolase(NSE),interleukin-1β(IL-1β)and brain-derived neurotrophic factor(BDNF)in adolescents with generalized anxiety disorder(GAD),so as to provide reference for the early diagnosis and evaluation of GAD in adolescents.Methods From March 2020 to February 2023,97 first-episode adoles-cents with generalized anxiety disorder aged 13-18 years were selected in the study.According to the score of generalized anxiety disorder questionnaire(GAD-7)on admission,they were divided into mild-moderate GAD group(58 cases)and severe GAD group(39 cases).At the same time,90 healthy adolescents who participated in routine physical examination in the same period were se-lected as the control group.Variance analysis was conducted for comparison among serum NSE,IL-1β and BDNF level.LSD-t was applied for further comparison,and the bivariate Pearson linear correlation analysis was carried out for the relationship among serum NSE,IL-1β and BDNF level.Results The differences among 3 groups of subjects on NSE and IL-1β,and BDNF were of statis-tical significance(F=10.73,12.80,20.67,P＜0.01),and the differences between groups were statistically significant(P＜0.05).In the control group,serum NSE level was(8.70±1.35)μg/L,IL-1β was(18.42±5.43)pg/mL,both were the lowest.The levels of NSE and IL-1β in severe GAD group were(14.21±3.25)μg/L,(26.04±5.39)pg/mL,which were the highest.The serum BD-NF level in control group was(27.16±4.42)ng/mL,which was the highest;and the severe GAD group was(10.46±3.27)ng/mL,which was the lowest.The bivariate Pearson linear correlation analysis showed that the serum NSE and IL-1β levels in GAD group were negatively correlated with the serum BDNF level(r=-0.49,-0.57);the serum NSE level was positively correlated with the IL-1β level(r=0.40)(P＜0.05).Conclusions The serum levels of NSE and IL-1β are abnormally increased in adolescents with GAD,and the serum levels of BDNF are significantly decreased.The serum levels of NSE,IL-1β and BDNF can be used as detec-tion markers for adolescent GAD,which is helpful for early diagnosis and disease evaluation.
AnxietySerumMental healthAnalysis of varianceAdolescent
NETL
NSTL
万方数据
