Objective To explore the impact of the sense of security on interpersonal relationships among impoverished college students,so as to provide empirical evidence for effective interpersonal communication cirsis prevention among impoverished college students.Methods In March 2023,a stratified random sampling method was used to select one university from Shanghai,Jiang-su,Henan,Anhui,Inner Mongolia,Gansu,Guangxi respatively.A total of 1 687 impoverished college students from 7 universities were surveyed using the Sense of Security Scale,Interpersonal Relationship Comprehensive Diagnosis Scale,Stress Perception Scale(SPS),and Mindfulness Attention Awareness Scale(MAAS).Moderated mediation effect analysis was performed using Model 7 in the SPSS macro program PROCESS.Results There was significant gender differences in the sense of security among impoverished college students(t=-2.31,P<0.05),and significant difference in interpersonal relationships by grade was observed(F=3.60,P<0.05).A sense of security was negatively associated with difficulties in interpersonal relationships among impoverished college students(β=-0.17,t=-9.27,P<0.01).Psychological stress partially mediates the relationship between the two,accounting for 19.54%of the total effect.Mindfulness regulates the first half of the path(β=0.10,t=5.32,P<0.01).Conclusions The sense of security shows impacts on interpersonal relationships among impoverished college students through psychological pressure.And it strengthens with the improvement of mindfulness level.Attention should be paid to cultivating a sense of security among impover-ished college students,improving their level of mindfulness,and preventing interpersonal crisis due to excessive psychological pres-sure.