Objective The study aims to analyze the prevalence and associated factors of myopia among 4 to 9 grade students in Guangdong Province in 2022,so as to provide a scientific basis for targeted intervention measures for myopia in children and adoles-cents.Methods From September to October 2022,stratified cluster random sampling was used to select 29 095 of 4 to 9 grade students from Guangzhou,Jiangmen,and Meizhou in Guangdong Province for myopia screening and questionnaire surveys.The Chi-square test was applied to compare the differences between groups,and multivariable Logistic stepwise regression analysis was used to analyze factors associated with myopia.Results The myopia detection rate of 4 to 9 grade students was 61.7%,with detection rates of 51.5%for 4 to 6 grade primary school students and 71.95%for 7 to 9 grade junior high school students.Multivariable Logis-tic regression analysis showed that higher myopia rates were detected among girls(OR=1.39,95%CI=1.30-1.49),students with one(OR=1.82,95%CI=1.69-1.96)or both parents having myopia(OR=2.86,95%CI=2.56-3.18),and indoor sedentary time>6 h(OR=1.28,95%CI=1.17-1.39)in the 4 to 6 grade.Lower myopia rates were detected in the county(OR=0.92,95%CI=0.86-0.99)and outdoors at recess activities(OR=0.88,95%CI=0.81-0.95).Meanwhile,higher myopia rates were detected among girls(OR=1.84,95%CI=1.69-1.99),students with one(OR=1.87,95%CI=1.71-2.04)or both parents having myopia(OR=3.03,95%CI=2.63-3.50),and indoor sedentary time>6 h/d(OR=1.11,95%CI=1.01-1.23)in the 7 to 9 grade.Lower myopia rates were detected in the county(OR=0.74,95%CI=0.68-0.80),outdoors at recess activities(OR=0.83,95%CI=0.76-0.91),and outdoor activity time ≥2 h/d(OR=0.87,95%CI=0.80-0.95)(P<0.05).Conclusions The detection rate of myopia among 4 to 9 grade students in Guangdong Province is relatively high.Place of recess activities,daily outdoor activity and indoor sedentary duration are associated with myopia.Therefore,targeted intervention measures should be adopted,such as appro-priately increasing outdoor activity to reduce the occurrence of myopia among primary and middle school students.