Prevalence of non-alcoholic fatty liver disease and associated factors in overweight and obese children in Hohhot
Objective To explore prevalence and associated factors of non-alcoholic fatty liver disease(NAFLD)in overweight and obese children in Hohhot City,so as to provide the oretical basis for developing health education plans and implementing pre-vention and treatment of NAFLD in children.Methods A total of 156 overweight and obese children was enrolled from 4 primary schools in Hohhot City using cluster sampling method during 28th Aug.2022 to 5th Mar.2023.Height and weight were measured and body mass index was calculated,and fasting blood was taken in the early morning for fasting blood glucose,alanine aminotrans-ferase,aspartate aminotransferase.Single factor analysis was conducted using t-test,X2 test and Fisher's exact probability method,while multivariate analysis was conducted using Logistic regression analysis and subject characteristic curves.Results The differ-ences in age,waist circumference,hip circumference,fasting glucose,alanine aminotransferase,aspartate aminotransferase,gam-ma glutamyltransferase,uric acid,and triglyceride were statistically significant between the non-NAFLD and the NAFLD group(U/t=1 070.0-2 164.0,P＜0.05).Significant differences were observed in aspartate aminotransferase(AST)and uric acid levels(AST OR=1.16,95％CI=1.04-1.28;uric OR=1.01,95％CI=1.00-1.01,P＜0.05).The area under a receiver operating characteristic were 0.737 for aspartate aminotransferase and 0.665 for uric acid,respectively.Conclusions The prevalence of NAFLD is high in overweight/obese children in Hohhot,and both elevated aspartate aminotransferase and hyperuricemia could increase the risk of NAFLD in overweight/obese children.Special attention should be paid to the NAFLD in overweight and obese children.It is recom-mended to reduce both BMI and uric level in the prevention and treatment of NAFLD to achieve better treatment outcomes.
OverweightObesityFatty liverPrevalenceRegression analysisChildMinority groups
NETL
NSTL
万方数据
