Effects of maximum fat oxidation intensity exercise combined with diet restriction on lipid and ferroptosis in obese college students with non-alcoholic fatty liver disease
Objective To compare the effects of 12-week maximum fat oxidation(FATmax)intensity exercise combined with di-etary restriction and FATmax intensity exercise alone on body composition,blood lipid metabolism and ferroptosis in obese college students with non-alcoholic fatty liver disease(NAFLD),so as to provide a exercise prescription reference for rehabilitation treatment of obese NAFLD college students.Methods In August 2023,a total of 45 obese NAFLD college students were divided into maxi-mum fat oxidation intensity exercise combined with dietary restriction group(FATmax+DR,n=22)and FATmax group(n=23)by random number table method,who were recruited through online notifications and physical examinations at the Physical Examination Center of Fenyang College of Shanxi Medical University.FATmax group received FATmax intensity exercise with 3 times a week for 12 weeks(FATmax:0.51 g/min,exercise intensity:50.14％VO2 max and the heart rate:136.78 times/min).FATmax+DR group underwent 12 weeks of FATmax intensity exercise combined with dietary restriction,and daily dietary energy intake was determined according to resting energy consumption.Body composition,four items of blood lipids and the indicators of oxidative stress and fer-roptosis were measured before and after the intervention.The differences of indicators among each group were analyzed by using inde-pendent sample t test and paired sample t test.Results Before the intervention,there were no significant differences in body com-position,four items of blood lipid,oxidative stress and iron death between FATmax+DR group and FATmax group(P＞0.05).After 12 weeks of intervention,body weight,body mass index(BMI),body fat mass,trunk fat mass,visceral fat area and serum low density lipoprotein(LDL)and malondialdehyde(MDA)levels in FATmax+DR group were significantly lower than those in FATmax group,while serum high density lipoprotein(HDL)and glutathione(GSH)levels were higher than those in FATmax group(t=-2.30,-3.23,-3.97,-5.85,-3.44,-3.06,-2.03,-2.09;2.73,2.42,P＜0.05).There were no significant differences in serum levels of total cholesterol(TC),triglyceride(TG),superoxide dismutase(SOD)and glutathion peroxidase 4(GPX4)between the two groups(t=1.49,1.00,-0.01,0.59,P＞0.05).Conclusion Twelve-week FATmax intensity exercise combined with dietary re-striction could significantly improve body composition and dyslipidemia,prevent the occurrence of ferroptosis and liver oxidative damage in obese NAFLD college students,which could serve as a timely promotion and application of intervention for obese college students with NAFLD.
Motor activityDietFatty liverLipid metabolismIntervention studiesStudents
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