Investigation of a kindergarten norovirus outbreak and detoxification time of infected children in Wuhan
Objective To analyze the characteristics of a norovirus outbreak in a kindergarten,and factors affecting the detoxifi-cation time,so as to provide a scientific basis for targeted control measures.Methods On February 24,2023,the basic personal information,clinical manifestations,morbidity and treatment of 16 kindergarten cases with a norovirus outbreak in Wuhan were col-lected.Anal swabs were collected every 7 d after the outbreak to detect norovirus.Chi-square test was used for comparison of inter-group rates.The comparison of detoxification time between different groups was conducted by Log-rank test,and the influencing fac-tors of detoxification time in cases were analyzed by Cox multiple regression analysis.Results From February 19-28,2023,a to-tal of 18 cases were reported and 16 of them participated in the detoxication time monitoring.In the first,second,third and fourth sampling after the outbreak,the positive rates were 60.00％,100.00％,75.00％and 0,respectively.The reverse transcriptionpoly-merase chain reaction cycle threshold(Ct values)were(25.83±5.74,28.83±5.55,36.13±4.30),and undetected,respectively.The median time of detoxification was 19.42 d with 95％CI=(18.21-20.64)d.The results of Cox regression showed that the detoxi-cation time was shorter in the treatment group than in the non-treatment group[HR(95％CI)=5.09(1.39-18.58),P＜0.05].Con-clusion Children infected with norovirus has a long duration of detoxification,and case management,which could be shortened by drugs,and disinfection should be strengthened after the case returned to school.
万方数据
维普
