转录组学蛋白组学和代谢组学生物标志物与儿童肥胖研究进展
Advances in biomarkers of transcriptomics,proteomics and metabolomics and childhood obesity
夏志伟 1沈葹 2王路 3孙冰洁 3殷继永 2霍军生 2郭欣3
作者信息
- 1. 北京市疾病预防控制中心学校卫生所,100013;中国疾病预防控制中心营养与健康所/国家卫生健康委公共营养与健康重点实验室
- 2. 中国疾病预防控制中心营养与健康所/国家卫生健康委公共营养与健康重点实验室
- 3. 北京市疾病预防控制中心学校卫生所,100013
- 折叠
摘要
组学生物标志物有助于提高人们对肥胖病因及其与慢性病联系的认识,文章概述了基于转录组学、蛋白组学、代谢组学肥胖表型生物标志物的最新进展,加深了对肥胖病因及干预效果异质性的理解;此外,将组学生物标志物应用到儿童肥胖精准防控中,不同组学生物标志物可以提高"肥胖"一词的精确度,并有助于早期检测具有风险特征的特定生物标志物,以便实现儿童肥胖从"一刀切"的防控策略转变为在肥胖发生发展过程中个性化的防治方案.
Abstract
Biomarkers could improve the understanding of the causes of obesity and its association with chronic diseases for peo-ple.The purpose of the review is to summarize recent advances in transcriptomic,proteomic,and metabolomic phenotypic biomark-ers of obesity in order to deepen the understanding of the etiology of obesity and its metabolic consequences.In the precise preven-tion and control of childhood obesity,different groups of biomarkers can improve the accuracy of the word"obesity"and help early detection of specific biomarkers with risk characteristics,so as to realize the transformation of childhood obesity from a one-size-fits-all prevention and control strategy to a personalized prevention and control plan during the development of obesity.
关键词
基因组学/蛋白质组学/生物学标记/肥胖症/儿童Key words
Genomics/Proteomics/Biological markers/Obesity/Child引用本文复制引用
基金项目
北京市卫生健康委员会高层次公共卫生技术人才建设项目(领军人才-01-09)
出版年
2024
NETL
NSTL
万方数据