Association between alanine aminotransferase levels and cardiac structure in childhood
Objective To explore the association between alanine aminotransferase(ALT)levels and cardiac structure in child-hood,so as to provide scientific evidence to promote childhood cardiac health.Methods Data were obtained from the baseline sur-vey of the"Huantai Childhood Cardiovascular Health Cohort Study"conducted from November 2017 to January 2018.A total of 1 340 children with complete data were included in the study.Demographic information and lifestyle factors were collected through questionnaires.Physical examinations and blood biochemical tests were performed to obtain children's body mass index(BMI),blood pressure,fasting plasma glucose(FPG),triglyceride(TG),high-density lipoprotein-cholesterol(HDL-C),low-density lip-oprotein-cholesterol(LDL-C),and ALT levels.Further,cardiac structural indicators such as left ventricular end-diastolic diameter(LVDD),left ventricular end-systolic diameter(LVSD),left ventricular posterior wall thickness(LVPWT),and interventricular septal thickness(IVST)were measured by ultrasound.Relative wall thickness(RWT),left ventricular mass(LVM),and left ven-tricular mass index(LVMI)were calculated.Multivariate linear regression models were used to analyze the relationship between ALT levels and cardiac structural indicators.Restricted cubic spline(RCS)models were used to explore the dose-response relation-ship between ALT levels and cardiac structural indicators.Results There were significant differences in LVDD,LVSD,IVST,LVPWT,LVM,LVMI and RWT in different ALT level groups(F=78.69,60.08,72.86,74.89,83.14,36.70,20.46,P＜0.05).Multivariate linear regression analysis showed that ALT levels were positively associated with LVDD,LVSD,IVST,LVPWT,LVM,and LVMI(β=0.10,0.20,0.16,0.16,0.23,0.18,P＜0.05)after adjusting for potential covariates.The RCS showed a lin-ear dose-response relationship between ALT levels and LVDD,LVSD,IVST,and LVMI after adjusting for potential covariates(Pnon-linear＞0.05).In contrast,a non-linear dose-response relationship was found between ALT levels and LVPWT and LVM(Pnon-linear＜0.05).Conclusions ALT levels in childhood are positively associated with the majority of cardiac structural indicators,presenting a linear or non-linear dose-response relationship.
万方数据
维普
