生命早期因素对肠道菌群与儿童肥胖的影响及干预研究进展
Research progress on the impact and intervention of early life factors on gut microbiota and childhood obesity
夏志伟 1宫照龙 2孙静 2郭欣 3李岩 2霍军生2
作者信息
- 1. 中国疾病预防控制中心营养与健康所中心实验室/国家卫生健康委员会公共营养与健康重点实验室,北京 100050;北京市疾病预防控制中心学校卫生所
- 2. 中国疾病预防控制中心营养与健康所中心实验室/国家卫生健康委员会公共营养与健康重点实验室,北京 100050
- 3. 北京市疾病预防控制中心学校卫生所
- 折叠
摘要
儿童肥胖是全球重大的公共卫生挑战之一,对儿童青少年的身心健康具有深远影响.文章综述生命早期肠道菌群的建立及早期营养状况与喂养方式、母婴菌群交换、分娩方式和抗菌药物使用等因素对肠道菌群及儿童肥胖的影响,重点探讨利用肠道菌群结构特征(基因丰富度和均匀度、细菌相对丰度比例及关键指示菌)作为肥胖儿童干预的潜在靶点和预测因子的可能性,并总结益生菌等生物制剂及肠道粪便转移在儿童肥胖干预中的应用及肠道菌群与儿童肥胖发生机制的最新进展,从而为精准防控儿童肥胖提供参考.
Abstract
Childhood obesity is one of the major global public health challenges and has a profound impact on the physical and mental health of children and adolescents.The article summarizes the establishment of gut microbiota in early life and the influences of early nutritional status and feeding patterns,maternal and infant microbiota transmission,delivery methods and the use of antibi-otics on gut microbiota and childhood obesity.The paper focuses on the possibility of using the structural characteristics of gut mi-crobiota(gene richness and evenness,relative abundance ratio and key indicator bacteria)as potential interventional targets and predictors of intervention effects in childhood obesity,and introduces the application of probiotics and other biological agents,as well as fecal microbiota transfer for the childhood obesity intervention,and briefly describes the latest progress in the mechanism of gut microbiota and childhood obesity,so as to provide the reference for the precise prevention and control of childhood obesity.
关键词
胃肠道/细菌/肥胖症/生命周期各时期/干预/儿童Key words
Gastrointestinal tract/Bacteria/Obesity/Life cycle stages/Intervention/Child引用本文复制引用
出版年
2024
NETL
NSTL
万方数据