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男男同性性行为学生HIV感染者抗病毒治疗现况及相关因素

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目的 探讨男男同性性行为(MSM)学生艾滋病病毒(HIV)感染者抗病毒治疗现状及相关因素,为HIV防治提供参考依据。方法 2021年11月招募中国31个省级行政区的137名MSM学生HIV感染者开展线上调查,描述人口学特征、抗逆转录病毒治疗(ART)服药情况及治疗前后的CD4和HIV病毒载量水平等。采用Logistic回归分析MSM学生抗病毒治疗效果的相关因素。结果 在纳入的研究对象中,14。6%为HIV晚发现,97。1%正在进行ART;排除启动治疗不足6个月的感染者后,病毒完全抑制率达到76。9%。Logistic回归分析结果显示,服药时间>24个月的学生HIV感染者(OR=5。28,95%CI=1。38~20。22)更可能ART抑制成功,报告有身体感受方面副作用(OR=0。08,95%CI=0。01~0。71)和认知方面副作用(OR=0。28,95%CI=0。09~0。90)的学生HIV感染者更可能造成ART抑制失败(P值均<0。05)。结论 MSM学生群体中ART的疗效仍有上升空间,应采取措施提高治疗依从性,在制定治疗方案时需充分考虑HIV感染者的个体差异和药物副作用。
Current status and related factors of antiviral treatment among HIV-infected men who have sex with men students
Objective To investigate the current situation and related factors of antiretroviral therapy(ART)among HIV-infec-ted male students engaging in men who have sex with men(MSM),so as to provide the reference data for HIV prevention and treat-ment.Methods In November 2021,137 MSM students from 31 provincial administrative regions in China were recruited.An on-line survey was conducted to collect data on demographic characteristics,ART status,CD4 count,and HIV viral load before treat-ment.Logistic regression was used to analyze the factors related the effectiveness of ART in MSM.Results Among the included re-search subjects,14.6%had late detection of HIV,97.1%of participants were currently undergoing ART.Among those whose ART duration was less than 6 months,while 76.9%were undergoing ART.Logistic regression indicated that HIV-infected students who received ART for more than 24 months(OR=5.28,95%CI=1.38-20.22)had a higher rate of successful HIV suppression.HIV-in-fected students who reported physical sensory side effects(OR=0.08,95%CI=0.01-0.71)and cognitive side effects(OR=0.28,95%CI=0.09-0.90)were more likely to experience failure of ARI inhibition(P<0.05).Conclusions There is still room for im-provement in the efficacy of ART among MSM students.Strategies to improve treatment adherence must consider individual vari-ances among HIV-infected patients and the side effects of medications when designing treatment plans.

Homosexuality,maleHIV infectionsRegression analysisStudents

岳腾、程朝御、鲜伊丹、刘萱、魏思月、刘媛媛、刘凤利、杨杰、于茂河、李长平、崔壮

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天津医科大学公共卫生学院流行病与卫生统计学系,天津 300070

天津深蓝公共卫生咨询服务中心

天津市疾病预防控制中心性病艾滋病预防控制所

同性恋,男性 HIV感染 回归分析 学生

2024

中国学校卫生
中华预防医学会

中国学校卫生

CSTPCD北大核心
影响因子:1.423
ISSN:1000-9817
年,卷(期):2024.45(12)