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虚拟临床试验应用现状及趋势

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虚拟临床试验是通过计算机模拟技术进行的临床试验,其突破了传统临床试验的限制,具有节省时间、降低成本、减少人体试验风险等优势.随着群体药代动力学、基于生理的药代动力学、系统定量药理学、人工智能等利用计算机进行建模与仿真新技术的应用,虚拟临床试验医疗健康领域已成为重要发展方向.本文将对虚拟临床试验的内涵、方法及未来发展趋势作初步综述,旨在为新技术、新方法在临床试验中的应用提供参考与借鉴.
Application status and development trend of virtual clinical trials
Virtual clinical trials are clinical trials conducted through computer simulation technology,which breaks through the limitations of traditional clinical trials and has the advantages of saving time,reducing costs,and reducing the risk of human trials.With the application of new computer technologies such as population pharmacokinetics,physiologically-based pharmacokinetics,quantitative systems pharmacology,and artificial intelligence,the field of virtual clinical trials in healthcare has become an important development direction.This article will give a preliminary review of the connotation,methods and future development trends of virtual clinical trials,aiming to provide reference for the application of new technologies and methods in clinical trials.

Virtual clinical trialsmodeling and simulationmodel-informed drug development

刘懿贤、郑莉

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四川大学华西医院临床试验中心(成都 610041)

四川大学华西医院国家药品监督管理局创新药物临床研究与评价重点实验室(成都 610041)

虚拟临床试验 建模与仿真 模型引导的药物研发

四川省科技厅重大专项

2020YFS0034

2024

中国胸心血管外科临床杂志
四川大学华西医院

中国胸心血管外科临床杂志

CSTPCD北大核心
影响因子:0.846
ISSN:1007-4848
年,卷(期):2024.31(2)
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