Sex hormone levels have little impact on outcomes of cardiac surgery in fertile women with congenital heart disease:A retrospective cohort study
Objective To examine the influence of hormonal fluctuations on the perioperative outcomes of patients undergoing congenital heart surgery.Methods We conducted a retrospective analysis of clinical data from fertile women diagnosed with congenital heart disease at the Guangdong Provincial People's Hospital,between January 1,2015,and July 30,2019.Initially,patients were categorized into groups based on serum progesterone levels:a low progesterone group(n=31)and a high progesterone group(n=153).Furthermore,based on serum estrogen levels,they were divided into a low estrogen group(n=10),a medium estrogen group(n=32),and a high estrogen group(n=1 18)for comparative analysis.A control group(n=24)consisted of patients who received progesterone injections before their menstrual period.Results We finally included 184 patients.The patients'average age was 27.6±5.7 years,with 142(77.17％)presenting with complex congenital heart conditions.There were statistically significant differences in total postoperative standard thoracic drainage volume and postoperative albumin level between the high and low progesterone groups(P＜0.05),while other perioperative outcome indicators showed no statistical differences(P＞0.05).Among the different serum estrogen level groups,there were statistically significant differences in postoperative blood urea nitrogen levels,total postoperative standard thoracic drainage volume,and hospital stay(P＜0.05),while other perioperative outcome indicators showed no statistical differences(P＞0.05).Conclusion Considering the overall clinical significance,the physiological changes in sex hormone levels appear to have a negligible effect on the perioperative outcomes of fertile women with congenital heart disease.
Sex hormonecardiac surgerycongenital heart diseasefertile women
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